ReviewBlood reviews2011
Manipulation of vascular function by blood flukes?
Review in Blood reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.Parasites & vectors · 2022Article
- Schistosomes Impede ATP-Induced T Cell Apoptosis In Vitro: The Role of Ectoenzyme SmNPP5.Pathogens (Basel, Switzerland) · 2022Article
- Serine proteases activity in miracidia ofVeterinary research forum : an international quarterly journal · 2021Article
- The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis.Virulence · 2020Article
- Kinins and Their Receptors in Infectious Diseases.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Basic Coagulation Profiles and Platelet Count AmongResearch and reports in tropical medicine · 2020Article
- Clinical Use ofFrontiers in immunology · 2020Review
- Vitamin B6 Acquisition and Metabolism inFrontiers in immunology · 2020Article
- SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.PLoS neglected tropical diseases · 2018Article
- The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.PLoS neglected tropical diseases · 2015Article
- Targeting of the hydrophobic metabolome by pathogens.Traffic (Copenhagen, Denmark) · 2015Review
- Genome and transcriptome of the porcine whipworm Trichuris suis.Nature genetics · 2014Article
- Excreted/secreted Schistosoma mansoni venom allergen-like 9 (SmVAL9) modulates host extracellular matrix remodelling gene expression.International journal for parasitology · 2014Article
- Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'.PLoS neglected tropical diseases · 2014Article
- Endothelial P2X7 receptors' expression is reduced by schistosomiasis.Purinergic signalling · 2013Article
- Interference with the host haemostatic system by schistosomes.PLoS pathogens · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Schistosomes (blood flukes) are long lived, intravascular parasites that afflict ~200 million people worldwide. Here we review the potential ability of these parasites to exert control on local vascular physiology. We examine schistosome kallikrein-like proteins that drive vasodilation. We review biogenic amine metabolism in the parasites that involve the vasodilator histamine and its receptors and the vasoconstrictor serotonin and its receptor. Schistosomes can trigger the release of histamine from host cells and can import serotonin. We consider the ability of schistosomes to generate and release the eicosanoid vasodilators PGD(2) and PGE(2) and the vasoconstrictors LTB(4) and LTC(4). The literature on nitric oxide metabolism in these blood flukes is assessed. Finally the potential impact of other schistosome metabolic processes (e.g. exogenous adenosine generation and acetylcholine degradation) on vascular function is appraised. An increased understanding of these processes could lead to novel anti-parasitics as well as new therapies to treat vascular dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.