ArticleArthritis research & therapy2011
Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip--an emerging genetic overlap.
Article in Arthritis research & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping review.Journal of hip preservation surgery · 2025Review
- Association between severe lumbar disc degeneration and end-stage hip or knee osteoarthritis requiring joint replacement surgery: a population-based cohort study with a 26-year follow-up.Archives of orthopaedic and trauma surgery · 2025Article
- Molecular mechanisms and genetic factors contributing to the developmental dysplasia of the hip.Frontiers in genetics · 2024Review
- Developmental dysplasia of the hip: a systematic literature review of the genes related with its occurrence.EFORT open reviews · 2019Review
- IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Article
- Osteoarthritis and intervertebral disc degeneration: Quite different, quite similar.JOR spine · 2018Review
- Genetic background of degenerative disc disease in the lumbar spine.Spine surgery and related research · 2018Review
- Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density.Frontiers in genetics · 2018Article
- The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.Scientific reports · 2016Article
- Risk factors for lumbar intervertebral disc height narrowing: a population-based longitudinal study in the elderly.BMC musculoskeletal disorders · 2015Article
- Etiology of osteoarthritis: genetics and synovial joint development.Nature reviews. Rheumatology · 2012Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetics highlights relationships between biological systems, and as the number of defined osteoarthritis susceptibility alleles increases, there is the natural tendency to assess whether the alleles influence other musculoskeletal phenotypes. That has proven to be the case for the GDF5 polymorphism rs143383, a risk factor for knee osteoarthritis and several other common conditions, including lumbar-disc degeneration and developmental dysplasia of the hip. Another interesting example has recently emerged in the repeat polymorphism of the asporin gene, ASPN, which is also associated with these three phenotypes. Such discoveries increase our understanding of shared disease etiology but also emphasize the complexity of common genetic risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.