ArticleNanomedicine (London, England)2011
Nanoparticle preconditioning for enhanced thermal therapies in cancer.
Article in Nanomedicine (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Computer simulation-based nanothermal field and tissue damage analysis for cardiac tumor ablation.Medical & biological engineering & computing · 2024Article
- Inorganic Nanoparticles as Radiosensitizers for Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2023Review
- Molecular immuno-imaging improves tumor detection in head and neck cancer.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Bubble-Manipulated Local Drug Release from a Smart Thermosensitive Cerasome for Dual-Mode Imaging Guided Tumor Chemo-Photothermal Therapy.Theranostics · 2019Article
- A brief review of cytotoxicity of nanoparticles on mesenchymal stem cells in regenerative medicine.International journal of nanomedicine · 2019Review
- Enhanced killing of HepG2 during cryosurgery with FeOncotarget · 2017Article
- Article
- Fe3O4 nanoparticles and cryoablation enhance ice crystal formation to improve the efficiency of killing breast cancer cells.Oncotarget · 2017Article
- NIR responsive liposomal system for rapid release of drugs in cancer therapy.International journal of nanomedicine · 2017Article
- Stem Cell Tracking with Nanoparticles for Regenerative Medicine Purposes: An Overview.Stem cells international · 2016Review
- Review
- Magnetic Nanoparticles in Cancer Theranostics.Theranostics · 2015Review
- In vivo detection of the effects of preconditioning on LNCaP tumors by a TNF-α nanoparticle construct using MRI.NMR in biomedicine · 2014Article
- Temperature of the magnetic nanoparticle microenvironment: estimation from relaxation times.Physics in medicine and biology · 2014Article
- In vivo photoacoustic lifetime imaging of tumor hypoxia in small animals.Journal of biomedical optics · 2013Article
- Nanoparticle delivered vascular disrupting agents (VDAs): use of TNF-alpha conjugated gold nanoparticles for multimodal cancer therapy.Molecular pharmaceutics · 2013Article
- The big picture on nanomedicine: the state of investigational and approved nanomedicine products.Nanomedicine : nanotechnology, biology, and medicine · 2013Review
- Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics.Scientific reports · 2013Article
- Magnetic fluid hyperthermia induced by radiofrequency capacitive field for the treatment of transplanted subcutaneous tumors in rats.Experimental and therapeutic medicine · 2012Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Nanoparticles show tremendous promise in the safe and effective delivery of molecular adjuvants to enhance local cancer therapy. One important form of local cancer treatment that suffers from local recurrence and distant metastases is thermal therapy. In this article, we review a new concept involving the use of nanoparticle-delivered adjuvants to 'precondition' or alter the vascular and immunological biology of the tumor to enhance its susceptibility to thermal therapy. To this end, a number of opportunities to combine nanoparticles with vascular and immunologically active agents are reviewed. One specific example of preconditioning involves a gold nanoparticle tagged with a vascular targeting agent (i.e., TNF-α). This nanoparticle embodiment demonstrates preconditioning through a dramatic reduction in tumor blood flow and induction of vascular damage, which recruits a strong and sustained inflammatory infiltrate in the tumor. The ability of this nanoparticle preconditioning to enhance subsequent heat or cold thermal therapy in a variety of tumor models is reviewed. Finally, the potential for future clinical imaging to judge the extent of preconditioning and thus the optimal timing and extent of combinatorial thermal therapy is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.