SynthesisHuman mutation2011
ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies.
Synthesis in Human mutation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 7 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Candidate gene polymorphisms and power athlete status: a meta-analytical approach.Journal of physiology and biochemistry · 2025Pooled it
- The frequency of the ACTN3 polymorphism in Brazil: a systematic review and meta-analysis.BMC medical genomics · 2025Pooled it
- A Systematic Review and Meta-analysis of the Association Between ACTN3 R577X Genotypes and Performance in Endurance Versus Power Athletes and Non-athletes.Sports medicine - open · 2024Pooled it
- Genetics of long-distance runners and road cyclists-A systematic review with meta-analysis.Scandinavian journal of medicine & science in sports · 2022Pooled it
- Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.PloS one · 2019Pooled it
- The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance.American journal of human genetics · 2018Pooled it
- The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.PloS one · 2013Pooled it
- Muscle Work and Its Relationship withGenes · 2021Trial
- Polymorphisms of PPARα and ACTN3 Among Adolescent Egyptian Athletes: A Case-Control Study.Life (Basel, Switzerland) · 2025Article
- The Distribution of Sport Performance Gene Variations Through COVID-19 Disease Severity.Diagnostics (Basel, Switzerland) · 2025Article
- The relationships between ACTN3 rs1815739 and PPARA-α rs4253778 gene polymorphisms and athletic performance characteristics in professional soccer players.BMC sports science, medicine & rehabilitation · 2023Article
- Association of theGenes · 2023Article
- Association ofGenes · 2023Article
- Associations of the Alpha-Actinin Three Genotype with Bone and Muscle Mass Loss among Middle-Aged and Older Adults.Journal of clinical medicine · 2022Article
- What Decides Your Athletic Career?-Reflection from Our Study of GP.Mur-Associated Sports Talents during the COVID-19 Pandemic Era.International journal of environmental research and public health · 2022Article
- The association ofBiology of sport · 2022Article
- Association of theGenes · 2022Article
- Article
- The ACE and ACTN3 polymorphisms in female soccer athletes.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Genetic test for the personalization of sport training.Acta bio-medica : Atenei Parmensis · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
Abstract
The ACTN3 R577X (rs1815739) genotype has been associated with athletic status and muscle phenotypes, although not consistently. Our objective was to conduct a meta-analysis of the published literature on athletic status and investigate its associations with physical capability in several new population-based studies. Relevant data were extracted from studies in the literature, comparing genotype frequencies between controls and sprint/power and endurance athletes. For life course physical capability, data were used from two studies of adolescents and seven studies in the Healthy Ageing across the Life Course (HALCyon) collaborative research program, involving individuals aged between 53 and 90+ years. We found evidence from the published literature to support the hypothesis that in Europeans the RR genotype is more common among sprint/power athletes compared with their controls. There is currently no evidence that the X allele is advantageous to endurance athleticism. We found no association between R577X and grip strength (P = 0.09, n = 7,672 in males; P = 0.90, n = 7,839 in females), standing balance, timed get up and go, or chair rises in our studies of physical capability. The ACTN3 R577X genotype is associated with sprint/power athletic status in Europeans, but does not appear to be associated with objective measures of physical capability in the general population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.