ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Vitamin K status in spaceflight and ground-based models of spaceflight.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 40 citations in OpenAlex.
- Early-phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training.European journal of applied physiology · 2014Trial
- Long-duration space flight and bed rest effects on testosterone and other steroids.The Journal of clinical endocrinology and metabolism · 2012Trial
- Time-resolved molecular measurements reveal changes in astronauts during spaceflight.Frontiers in physiology · 2023Article
- Article
- Long-Term Space Nutrition: A Scoping Review.Nutrients · 2021Article
- Spaceflight Induced Disorders: Potential Nutritional Countermeasures.Frontiers in bioengineering and biotechnology · 2021Review
- Article
- Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
- Excretion of Zinc and Copper Increases in Men during 3 Weeks of Bed Rest, with or without Artificial Gravity.The Journal of nutrition · 2017Article
- Falls and Fall-Prevention in Older Persons: Geriatrics Meets Spaceflight!Frontiers in physiology · 2017Review
- Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities.NPJ microgravity · 2016Review
- Magnesium and Space Flight.Nutrients · 2015Article
- Sex-specific responses of bone metabolism and renal stone risk during bed rest.Physiological reports · 2014Article
- Space flight calcium: implications for astronaut health, spacecraft operations, and Earth.Nutrients · 2012Review
- Bone metabolism and nutritional status during 30-day head-down-tilt bed rest.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Bone loss is a well-documented change during and after long-duration spaceflight. Many types of countermeasures to bone loss have been proposed, including vitamin K supplementation. The objective of this series of studies was to measure change in vitamin K status in response to microgravity under a variety of spaceflight and spaceflight analog (model) conditions, including long-duration spaceflight studies (n = 15), three bed rest studies (n = 15, 49, and 24), and a 14-day saturation dive (n = 6). In crew members who flew 2-6 months on the International Space Station, in-flight and postflight plasma phylloquinone concentrations were unchanged from the preflight mean. Consistent with this finding, urinary γ-carboxyglutamic acid (GLA), a measure of vitamin K-dependent protein turnover, did not change in response to flight. Serum undercarboxylated osteocalcin (%ucOC), a measure of vitamin K function, was generally unchanged in response to flight. Spaceflight findings were corroborated by findings of no changes in phylloquinone, urinary GLA, or %ucOC during or after bed rest in three separate bed rest studies (21-90 days in duration) or after a 14-day saturation dive. The data presented here do not support either a need for vitamin K supplementation during spaceflight or the suggestion of using vitamin K as a bone loss countermeasure in spaceflight.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.