ArticleJournal of molecular histology2011
Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury.
Article in Journal of molecular histology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Prognostic and Immunomodulatory Roles of PAK6 in Colorectal Cancer Through Integrative Transcriptomic and Clinical Analysis.Cancers · 2025Article
- Upregulation of G-protein Coupled Receptor 120 in Rats Following Spinal Cord Injury.Neurochemical research · 2022Article
- Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury.Frontiers in neuroscience · 2021Article
- Review
- LIN28 expression in rat spinal cord after injury.Neurochemical research · 2014Article
- Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats.Journal of molecular neuroscience : MN · 2014Article
- The expression of FBP1 after traumatic brain injury and its role in astrocyte proliferation.Journal of molecular neuroscience : MN · 2013Article
- SCY1-like 1 binding protein 1 (SCYL1-bp1) interacts with p53-induced RING H2 protein (Pirh2) after traumatic brain injury in rats.Journal of molecular histology · 2013Article
- Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats.Journal of molecular histology · 2013Article
- Expression of RBMX after spinal cord injury in rats.Journal of molecular neuroscience : MN · 2013Article
- Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury.Journal of molecular histology · 2013Article
- Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.Biological psychiatry · 2012Article
- PAK4-6 in cancer and neuronal development.Cellular logistics · 2012Article
- Increased expression of calcium/calmodulin-dependent protein kinase type II subunit δ after rat traumatic brain injury.Journal of molecular neuroscience : MN · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p21-activated Kinase 6 (PAK6) is a serine/threonine kinase belonging to the p21-activated kinase (PAK) family. PAK kinases are well-known regulators of a wide variety of cellular functions, including regulation of cytoskeleton rearrangement, cell survival, apoptosis and the mitogen-activated protein kinase signaling pathway. To elucidate the expressions and possible functions of PAK6 in central nervous system (CNS) lesion and repair, we performed a traumatic brain injury (TBI) model in adult rats. Western blot analysis revealed that PAK6 level significantly increased at day 3 after damage, and then declined during the following days. Besides, double immunofluorescence staining showed PAK6 was primarily expressed in the neurons and a few of glial cells in the normal group. While after injury, the expression of PAK6 was increased significantly in the astrocytes and neurons, and the astrocytes had largely proliferated. We also examined the expression of proliferating cell nuclear antigen (PCNA) whose change was correlated with the expression of PAK6. Importantly, double immunofluorescence staining revealed that cell proliferation evaluated by PCNA appeared in many PAK6-expressing cells at day 3 after injury. In addition, injury-induced expression of PAK6 was co-labeled by active caspase-3 during neuronal apoptosis after injury. Collectively, we hypothesized PAK6 may play important roles in CNS pathophysiology after TBI and further research is needed to have a good understanding of its function and mechanism.
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