ArticleAge (Dordrecht, Netherlands)2012
Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort.
Article in Age (Dordrecht, Netherlands), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed.
- Changes in Muscle Mass and the Risk of Liver-Related Events: A Prospective Cohort Study.Diabetes, obesity & metabolism · 2026Article
- Evaluating a Genome-Wide Polygenic Score for Handgrip Strength and Its Interplay with Leisure-Time Physical Activity Across the IGEMS Twin Cohorts.Medicine and science in sports and exercise · 2026Article
- Contribution of Sport Type to the Association Between Handgrip Strength and Morbidity/Mortality: Future Follow-up Study and Possible Mechanisms.Sports medicine - open · 2026Review
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Trajectories of episodic memory in midlife: Historical change from a cross-country perspective.Psychology and aging · 2025Article
- Associations Between Upper Extremity Activity Capacity and Strength and Post-Operative Ambulation After Geriatric Hip Fracture: A Prospective Controlled Study.Journal of clinical medicine · 2025Article
- Self-reported, functional, and objective health and sociodemographic characteristics among older adults in Kenya: findings from the pilot longitudinal study of health and ageing in Kenya (LOSHAK).Frontiers in aging · 2025Article
- Handgrip strength as a prognostic factor for COVID-19 mortality among older adult patients admitted to the intensive care unit (ICU): a comparison Alpha (B.1.1.7) and Delta (B.1.617.2) variants.Scientific reports · 2024Article
- The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice.GeroScience · 2024Article
- Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Which trunk muscle parameter is the best predictor for physical function in older adults?Heliyon · 2023Article
- Exploring Handgrip Strength as a Cross-cultural Correlate of Body Composition and Upper Body Strength in Older Adults from Costa Rica and Kansas.Journal of cross-cultural gerontology · 2023Article
- Development and Validation of a Lifespan Prediction Model in Chinese Adults Aged 65 Years or Older.Journal of the American Medical Directors Association · 2023Article
- The molecular athlete: exercise physiology from mechanisms to medals.Physiological reviews · 2023Review
- Resilience among older adults during the COVID-19 pandemic: A photovoice study.SSM. Qualitative research in health · 2023Article
- Functional muscle power in the lower extremity in adults with congenital heart disease.International journal of cardiology. Congenital heart disease · 2023Article
- Article
- Muscular Strength in Risk Factors for Cardiovascular Disease and Mortality: A Narrative Review.Anatolian journal of cardiology · 2022Review
- Associations of handgrip strength with all-cause and cancer mortality in older adults: a prospective cohort study in 28 countries.Age and ageing · 2022Article
- Correlation between hand grip strength and regional muscle mass in older Asian adults: an observational study.BMC geriatrics · 2022Observational
12 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
We studied prospectively the midlife handgrip strength, living habits, and parents' longevity as predictors of length of life up to becoming a centenarian. The participants were 2,239 men from the Honolulu Heart Program/Honolulu-Asia Aging Study who were born before the end of June 1909 and who took part in baseline physical assessment in 1965-1968, when they were 56-68 years old. Deaths were followed until the end of June 2009 for 44 years with complete ascertainment. Longevity was categorized as centenarian (≥100 years, n = 47), nonagenarian (90-99 years, n = 545), octogenarian (80-89 years, n = 847), and ≤79 years (n = 801, reference). The average survival after baseline was 20.8 years (SD = 9.62). Compared with people who died at the age of ≤79 years, centenarians belonged 2.5 times (odds ratio (OR) = 2.52, 95% confidence interval (CI) = 1.23-5.10) more often to the highest third of grip strength in midlife, were never smokers (OR = 5.75 95% CI = 3.06-10.80), had participated in physical activity outside work (OR = 1.13 per daily hour, 95% CI = 1.02-1.25), and had a long-lived mother (≥80 vs. ≤60 years, OR = 2.3, 95% CI = 1.06-5.01). Associations for nonagenarians and octogenarians were parallel, but weaker. Multivariate modeling showed that mother's longevity and offspring's grip strength operated through the same or overlapping pathway to longevity. High midlife grip strength and long-lived mother may indicate resilience to aging, which, combined with healthy lifestyle, increases the probability of extreme longevity.
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