ArticleCellular oncology (Dordrecht, Netherlands)2011
Genetic profile of adenoid cystic carcinomas (ACC) with high-grade transformation versus solid type.
Article in Cellular oncology (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Basaloid-Solid Adenoid Cystic Carcinoma of the Breast: A Case Report and Literature Review.Case reports in pathology · 2026Article
- Enhanced Transcriptional Signature and Expression of Histone-Modifying Enzymes in Salivary Gland Tumors.Cells · 2023Article
- Lacrimal Gland Adenoid Cystic Carcinoma with High Grade Transformation: A Case Report and Current Concepts in Multi Modality Management.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2022Article
- Adenoid Cystic Carcinoma with Transformation to High Grade Carcinomatous and Sarcomatoid Components: A Rare Case Report with Review of Literature.Head and neck pathology · 2020Review
- Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?Virchows Archiv : an international journal of pathology · 2016Article
- Genetic events in the progression of adenoid cystic carcinoma of the breast to high-grade triple-negative breast cancer.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review.Auris, nasus, larynx · 2016Review
- Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.Advances in therapy · 2016Review
- Analysis of MYB oncogene in transformed adenoid cystic carcinomas reveals distinct pathways of tumor progression.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- High-grade transformation of adenoid cystic carcinoma delineated with a fibrous rim: a case report.Balkan medical journal · 2013Article
- "Dedifferentiation" and high-grade transformation in salivary gland carcinomas.Head and neck pathology · 2013Review
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundACC can occasionally undergo dedifferentiation also referred to as high-grade transformation (ACC-HGT). However, ACC-HGT can also undergo transformation to adenocarcinomas which are not poorly differentiated. ACC-HGT is generally considered to be an aggressive variant of ACC, even more than solid ACC. This study was aimed to describe the genetic changes of ACC-HGT in relation to clinico-pathological features, and to compare results to solid ACC.
methodsGenome wide DNA copy number changes were analyzed by microarray CGH in ACC-HGT, four with transformation into moderately differentiated adenocarcinoma (MDA) and two into poorly differentiated carcinoma (PDC), and five solid ACC. In addition, Ki67 index and p53 immunopositivity was assessed.
resultsACC-HGT carried fewer copy number changes compared to solid ACC. Two ACC-HGT cases harboured a breakpoint at 6q23, near the cMYB oncogene. The complexity of the genomic profile concurred with the clinical course of the patient. Among the ACC-HGT, p53 positivity significantly increased from the conventional to the transformed (both MDA and PDC) component.
conclusionACC-HGT may not necessarily reflect a more advanced stage of tumor progression, but rather a transformation to another histological form in which the poorly differentiated forms (PDC) presents a genetic complexity similar to the solid ACC.
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