ArticlePLoS biology2011
Force-velocity measurements of a few growing actin filaments.
Article in PLoS biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Biophysical Modeling of Actin-Mediated Structural Plasticity Reveals Mechanical Adaptation in Dendritic Spines.eNeuro · 2024Article
- Nascent adhesions shorten the period of lamellipodium protrusion through the Brownian ratchet mechanism.Molecular biology of the cell · 2023Article
- Dynamic interfaces for contact-time control of colloidal interactions.Soft matter · 2023Article
- Zero-mode waveguides visualize the first steps during gelsolin-mediated actin filament formation.Biophysical journal · 2022Article
- A continuum model for the growth of dendritic actin networks.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes.Nature communications · 2020Article
- Actin filaments pushing against a barrier: Comparison between two force generation mechanisms.The European physical journal. E, Soft matter · 2019Article
- How a High-Gradient Magnetic Field Could Affect Cell Life.Scientific reports · 2016Article
- Article
- Power transduction of actin filaments ratcheting in vitro against a load.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Load sharing in the growth of bundled biopolymers.New journal of physics · 2014Article
- Control of actin-based motility through localized actin binding.Physical biology · 2013Article
- Impact of branching on the elasticity of actin networks.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Microfluidics pushes forward microscopy analysis of actin dynamics.Bioarchitecture · 2011Article
- Cell motility: the integrating role of the plasma membrane.European biophysics journal : EBJ · 2011Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The polymerization of actin in filaments generates forces that play a pivotal role in many cellular processes. We introduce a novel technique to determine the force-velocity relation when a few independent anchored filaments grow between magnetic colloidal particles. When a magnetic field is applied, the colloidal particles assemble into chains under controlled loading or spacing. As the filaments elongate, the beads separate, allowing the force-velocity curve to be precisely measured. In the widely accepted Brownian ratchet model, the transduced force is associated with the slowing down of the on-rate polymerization. Unexpectedly, in our experiments, filaments are shown to grow at the same rate as when they are free in solution. However, as they elongate, filaments are more confined in the interspace between beads. Higher repulsive forces result from this higher confinement, which is associated with a lower entropy. In this mechanism, the production of force is not controlled by the polymerization rate, but is a consequence of the restriction of filaments' orientational fluctuations at their attachment point.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.