ArticlePLoS neglected tropical diseases2011
Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases.
Article in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
- Improving Wolbachia-based control programs in urban settings: Insights from spatial modeling.PLoS neglected tropical diseases · 2025Article
- Comparative Endosymbiont Community Structures of Nonviruliferous and Rice Stripe Virus-ViruliferousViruses · 2025Article
- Gene drives: an alternative approach to malaria control?Gene therapy · 2025Review
- Genomic Underpinnings of Cytoplasmic Incompatibility: CIF Gene-Neighborhood Diversification Through Extensive Lateral Transfers and Recombination in Wolbachia.Genome biology and evolution · 2024Article
- Wolbachia confers protection against the entomopathogenic fungus Metarhizium pingshaense in African Aedes aegypti.Environmental microbiology reports · 2024Article
- Tolerance-conferring defensive symbionts and the evolution of parasite virulence.Evolution letters · 2023Article
- First Detection and Genetic Identification ofMicroorganisms · 2023Article
- The Dynamic Distribution ofInsects · 2023Article
- Variation of endosymbiont andFrontiers in microbiology · 2023Article
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- Using models and maps to inform Target Product Profiles and Preferred Product Characteristics: the example ofGates open research · 2023Article
- The phylogeny and distribution ofFrontiers in cellular and infection microbiology · 2023Article
- Analysis of Intestinal Microbial Diversity of Four Species of Grasshoppers and Determination of Cellulose Digestibility.Insects · 2022Article
- Lab-scale characterization and semi-field trials of Wolbachia Strain wAlbB in a Taiwan Wolbachia introgressed Ae. aegypti strain.PLoS neglected tropical diseases · 2022Article
- Public sentiments towards the use of Wolbachia-Aedes technology in Singapore.BMC public health · 2021Article
- Prevalence of Larval Breeding Sites and Seasonal Variations ofInternational journal of environmental research and public health · 2021Article
- The Axenic and Gnotobiotic Mosquito: Emerging Models for Microbiome Host Interactions.Frontiers in microbiology · 2021Review
- Review
- Modeling and dynamics of Wolbachia-infected male releases and mating competition on mosquito control.Journal of mathematical biology · 2020Article
- Wolbachia strain wAlbA blocks Zika virus transmission in Aedes aegypti.Medical and veterinary entomology · 2020Article
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Authors and funding
3 authors.
Funding
Abstract
Certain strains of the endosymbiont Wolbachia have the potential to lower the vectorial capacity of mosquito populations and assist in controlling a number of mosquito-borne diseases. An important consideration when introducing Wolbachia-carrying mosquitoes into natural populations is the minimisation of any transient increase in disease risk or biting nuisance. This may be achieved by predominantly releasing male mosquitoes. To explore this, we use a sex-structured model of Wolbachia-mosquito interactions. We first show that Wolbachia spread can be initiated with very few infected females provided the infection frequency in males exceeds a threshold. We then consider realistic introduction scenarios involving the release of batches of infected mosquitoes, incorporating seasonal fluctuations in population size. For a range of assumptions about mosquito population dynamics we find that male-biased releases allow the infection to spread after the introduction of low numbers of females, many fewer than with equal sex-ratio releases. We extend the model to estimate the transmission rate of a mosquito-borne pathogen over the course of Wolbachia establishment. For a range of release strategies we demonstrate that male-biased release of Wolbachia-infected mosquitoes can cause substantial transmission reductions without transiently increasing disease risk. The results show the importance of including mosquito population dynamics in studying Wolbachia spread and that male-biased releases can be an effective and safe way of rapidly establishing the symbiont in mosquito populations.
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