ReviewJournal of biomedicine & biotechnology2011
Roles of the WHHL rabbit in translational research on hypercholesterolemia and cardiovascular diseases.
Review in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Potential role of different animal models for the evaluation of bioactive compounds.Annals of medicine and surgery (2012) · 2025Review
- Current status and challenges of multi-omics research using animal models of atherosclerosis.Journal of molecular and cellular cardiology plus · 2025Review
- Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.Life sciences in space research · 2023Article
- Role of animal models in biomedical research: a review.Laboratory animal research · 2022Review
- Article
- Time-restricted feeding prevents high-fat and high-cholesterol diet-induced obesity but fails to ameliorate atherosclerosis in apolipoprotein E-knockout mice.Experimental animals · 2021Article
- Hypercholesterolemia negatively influences morphology and molecular markers of epithelial cells within the choroid plexus in rabbits.Fluids and barriers of the CNS · 2020Article
- Animal models of coronary heart disease.Journal of biomedical research · 2015Article
- Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.Pharmacology & therapeutics · 2015Review
- Characteristic patterns of maternal and fetal arterial construction in the rabbit placenta.Medical molecular morphology · 2014Article
- Article
- Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs.PloS one · 2014Article
- The effects of jiang-zhi-ning and its main components on cholesterol metabolism.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Thermal intravascular photoacoustic imaging.Biomedical optics express · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conquering cardiovascular diseases is one of the most important problems in human health. To overcome cardiovascular diseases, animal models have played important roles. Although the prevalence of genetically modified animals, particularly mice and rats, has contributed greatly to biomedical research, not all human diseases can be investigated in this way. In the study of cardiovascular diseases, mice and rats are inappropriate because of marked differences in lipoprotein metabolism, pathophysiological findings of atherosclerosis, and cardiac function. On the other hand, since lipoprotein metabolism and atherosclerotic lesions in rabbits closely resemble those in humans, several useful animal models for these diseases have been developed in rabbits. One of the most famous of these is the Watanabe heritable hyperlipidemic (WHHL) rabbit, which develops hypercholesterolemia and atherosclerosis spontaneously due to genetic and functional deficiencies of the low-density lipoprotein (LDL) receptor. The WHHL rabbit has been improved to develop myocardial infarction, and the new strain was designated the myocardial infarction-prone WHHL (WHHLMI) rabbit. This review summarizes the importance of selecting animal species for translational research in biomedical science, the development of WHHL and WHHLMI rabbits, their application to the development of hypocholesterolemic and/or antiatherosclerotic drugs, and future prospects regarding WHHL and WHHLMI rabbits.
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