ArticleInternational journal of molecular sciences2011
Accounting for large amplitude protein deformation during in silico macromolecular docking.
Article in International journal of molecular sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- Pushing the Backbone in Protein-Protein Docking.Structure (London, England : 1993) · 2016Article
- Balancing target flexibility and target denaturation in computational fragment-based inhibitor discovery.Journal of computational chemistry · 2012Article
- Protein-protein HADDocking using exclusively pseudocontact shifts.Journal of biomolecular NMR · 2011Article
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Authors and funding
3 authors.
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Abstract
Rapid progress of theoretical methods and computer calculation resources has turned in silico methods into a conceivable tool to predict the 3D structure of macromolecular assemblages, starting from the structure of their separate elements. Still, some classes of complexes represent a real challenge for macromolecular docking methods. In these complexes, protein parts like loops or domains undergo large amplitude deformations upon association, thus remodeling the surface accessible to the partner protein or DNA. We discuss the problems linked with managing such rearrangements in docking methods and we review strategies that are presently being explored, as well as their limitations and success.
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