ArticlePLoS genetics2011
A sustained dietary change increases epigenetic variation in isogenic mice.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- A randomized controlled trial of folic acid intervention in pregnancy highlights a putative methylation-regulated control element at ZFP57.Clinical epigenetics · 2019Trial
- DNA Methylation in Periodontal Disease: A Focus on Folate, Folic Acid, Mitochondria, and Dietary Intervention.International journal of molecular sciences · 2025Review
- Placental mRNA and miRNA dynamics associated with lipid metabolism pathways in pregnancies affected by obesity.Frontiers in endocrinology · 2025Article
- Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota.Nutrients · 2024Review
- Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny.Molecular neurobiology · 2020Article
- Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Dietary Modulation of the Epigenome.Physiological reviews · 2018Review
- Incorporation of an Epigenetic Evaluation into Safety Assessment: What we First Need to Know.Current opinion in toxicology · 2017Article
- Show and tell: disclosure and data sharing in experimental pathology.Disease models & mechanisms · 2016Review
- Epigenetic modulation of DNA methylation by nutrition and its mechanisms in animals.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2015Review
- Dietary Selenium Levels Affect Selenoprotein Expression and Support the Interferon-γ and IL-6 Immune Response Pathways in Mice.Nutrients · 2015Article
- Successive Generations in a Rat Model Respond Differently to a Constant Obesogenic Environment.PloS one · 2015Article
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?Clinical epigenetics · 2015Article
- The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences.Nature communications · 2014Article
- Early developmental conditioning of later health and disease: physiology or pathophysiology?Physiological reviews · 2014Review
- Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain.Translational psychiatry · 2014Article
- Gene expression in teratogenic exposures: a new approach to understanding individual risk.Reproductive toxicology (Elmsford, N.Y.) · 2014Article
- Epigenomic programing: a future way to health?Microbial ecology in health and disease · 2014Review
- Maternal methyl supplemented diets and effects on offspring health.Frontiers in genetics · 2014Review
- Genetic, epigenetic, and environmental contributions to neural tube closure.Annual review of genetics · 2014Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic changes can be induced by adverse environmental exposures, such as nutritional imbalance, but little is known about the nature or extent of these changes. Here we have explored the epigenomic effects of a sustained nutritional change, excess dietary methyl donors, by assessing genomic CpG methylation patterns in isogenic mice exposed for one or six generations. We find stochastic variation in methylation levels at many loci; exposure to methyl donors increases the magnitude of this variation and the number of variable loci. Several gene ontology categories are significantly overrepresented in genes proximal to these methylation-variable loci, suggesting that certain pathways are susceptible to environmental influence on their epigenetic states. Long-term exposure to the diet (six generations) results in a larger number of loci exhibiting epigenetic variability, suggesting that some of the induced changes are heritable. This finding presents the possibility that epigenetic variation within populations can be induced by environmental change, providing a vehicle for disease predisposition and possibly a substrate for natural selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.