ArticleWorld journal of biological chemistry2010
Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism.
Article in World journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 117 citations in OpenAlex.
- Identification and determination of selenoneine, 2-selenyl-N α , N α , N α -trimethyl-L-histidine, as the major organic selenium in blood cells in a fish-eating population on remote Japanese Islands.Biological trace element research · 2013Trial
- XFM and HERFD-XAS studies of selenium in tissues and whole blood from mice supplemented with potentially therapeutic selenocompounds.Redox report : communications in free radical research · 2026Article
- Natural Histidine Derivatives-From Basic Research to Potential Applications in Cosmetics and Nutricosmetics.Antioxidants (Basel, Switzerland) · 2026Review
- Selenosugars in Animals and Humans: Operational Nomenclature, Analysis, Occurrence, and Metabolic Pathways.Biological trace element research · 2026Review
- Selenium Speciation in Commonly Consumed Thai Seafood Under Different Cooking Methods.Foods (Basel, Switzerland) · 2026Article
- Selenoneine, a food chain component with potential neuroprotective effects against electrophilic mercury forms.Advances in neurotoxicology · 2026Article
- The impact of various selenium forms during the maturation period of Gilthead seabream (Sparus aurata) broodstock on the reproductive performance, egg, and offspring quality.Scientific reports · 2025Article
- Selenoneine and ergothioneine in beluga skin and tissues as key antioxidants in the Inuit diet.Scientific reports · 2025Article
- Synthesis, Characterization, and DFT Studies of NHC-Derived Amide-Functionalized Organoselenium Compounds.ACS omega · 2025Article
- Maternal seafood consumption is associated with improved selenium status: Implications for child health.Neurotoxicology · 2024Article
- Determinants of iron deficiency and anemia among Nunavimmiut: results from the Qanuilirpitaa? 2017 Nunavik Health Survey.Canadian journal of public health = Revue canadienne de sante publique · 2024Article
- Comparison of Muscle Color and Total Selenium Concentrations Between Spotted Mackerel Scomber australasicus and Pacific Mackerel S. japonicus.Marine biotechnology (New York, N.Y.) · 2023Article
- Nutritional Supplementation and Enhanced Antioxidant Function by Dietary Intake of Selenoneine and Other Selenium Compounds in Red Seabream Pagrus major.Marine biotechnology (New York, N.Y.) · 2023Article
- Assessing the role of the gut microbiome in methylmercury demethylation and elimination in humans and gnotobiotic mice.Archives of toxicology · 2023Article
- Antioxidant Activities and Selenogene Transcription in the European Sea Bass (Dicentrarchus labrax) Liver Depend, in a Non-linear Manner, on the Se/Hg Molar Ratio of the Feeds.Biological trace element research · 2022Article
- Ergothioneine, Ovothiol A, and Selenoneine-Histidine-Derived, Biologically Significant, Trace Global Alkaloids.Molecules (Basel, Switzerland) · 2022Review
- Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase.Antioxidants (Basel, Switzerland) · 2022Article
- Dietary Intake of Selenoneine Enhances Antioxidant Activity in the Muscles of the Amberjack Seriola dumerili Grown in Aquaculture.Marine biotechnology (New York, N.Y.) · 2021Article
- Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Implications for an imidazol-2-yl carbene intermediate in the rhodanase-catalyzed C-S bond formation reaction of anaerobic ergothioneine biosynthesis.ACS catalysis · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel selenium-containing compound, selenoneine, has been isolated as the major form of organic selenium in the blood and tissues of tuna. Selenoneine harbors a selenium atom in the imidazole ring, 2-selenyl-N(α), N(α), N(α)-trimethyl-L-histidine, and is a selenium analog of ergothioneine. This selenium compound has strong antioxidant capacity and binds to heme proteins, such as hemoglobin and myoglobin, to protect them from iron auto-oxidation, and it reacts with radicals and methylmercury (MeHg). The organic cations/carnitine transporter OCTN1 transports selenoneine and MeHg, regulates Se-enhanced antioxidant activity, and decreases MeHg toxicity. Thus, the dietary intake of selenoneine, by consuming fish, might decrease the formation of reactive oxygen radicals that could oxidize nucleotides in DNA, and thereby inhibit carcinogenesis, chronic diseases, and aging.
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