Evidence map›Paper›PMID 21540989›Full record

ArticleWorld journal of biological chemistry2010

Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.

Noula Shembade, Edward W Harhaj

Open access · hybridAbstract read
In one paragraph

Article in World journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  6. Role of Exosomes in Human Retroviral Mediated Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018
    Review
  7. Exosomes in Viral Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016
    Review
  8. Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Noula ShembadeNoula Shembade, Edward W Harhaj, Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, United States.
Edward W Harhaj
Sylvester Comprehensive Cancer Center · US

Funding

Tissue/Pathology CoreP01CA128115 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GUETTOUCHE, TOUMY · 2009 to 2013
$5.6M
Mechanisms of HTLV-I Tax-mediated NF-kB activationR01CA135362 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARHAJ, EDWARD W · 2009 to 2018
$2.7M
Negative regulation of NF-kB and inflammation by TAX1BP1R01GM083143 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARHAJ, EDWARD W · 2009 to 2012
$1.2M
NCI NIH HHS P01 CA128115NCI NIH HHS R01 CA135362NIGMS NIH HHS R01 GM083143
6 · The paper itself

Abstract

Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus discovered, is the etiological agent of adult-T-cell leukemia/lymphoma. The HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene expression by constitutively activating nuclear factor-κB (NF-κB). Tax activation of NF-κB is critical for the immortalization and survival of HTLV-1-infected T cells. In this review, we summarize the present knowledge on mechanisms underlying Tax-mediated NF-κB activation, with an emphasis on post-translational modifications of Tax.

Indexed as

Adult-T-cell leukemia/lymphomaHuman T-cell leukemia virus type 1Human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesisIKKNuclear factor-κB

Identifiers

PMID21540989
PMCPMC3083931
OpenAlexW2042035833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.