ArticleThe Journal of physiology2011
Force decline during fatigue is due to both a decrease in the force per individual cross-bridge and the number of cross-bridges.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- Phosphate and acidosis cause fibre type-specific changes to cellular and molecular contractile mechanics at 37°C in skeletal muscle from older adults.Experimental physiology · 2026Article
- Skeletal muscle knockout of NAD(P)H oxidase 2 delays the development of isotonic diaphragm fatigue in mice.Free radical biology & medicine · 2025Article
- Neuromuscular fatigue reduces force responsiveness when controlling leg external forces.Physiological reports · 2025Article
- Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog.American journal of physiology. Cell physiology · 2025Article
- Does the unusual phenomenon of sustained force circumvent the speed-endurance trade-off in the jaw muscle of the southern alligator lizard (Elgaria multicarinata)?The Journal of experimental biology · 2025Article
- Article
- Comparing the acute responses between a manual and automated blood flow restriction system.Frontiers in physiology · 2024Article
- A comparison of individual force decline profiles during a fatiguing eccentric trunk flexion and extension protocol: a pilot study.Frontiers in sports and active living · 2024Article
- Association between elite swimmers' force production and 100 m front crawl inter-lap pacing and kinematics.Frontiers in sports and active living · 2023Article
- Changes in electromyographic activity, mechanical power, and relaxation rates following inspiratory ribcage muscle fatigue.Scientific reports · 2021Observational
- Peripheral fatigue: new mechanistic insights from recent technologies.European journal of applied physiology · 2020Review
- Evidence for Muscle Cell-Based Mechanisms of Enhanced Performance in Stretch-Shortening Cycle in Skeletal Muscle.Frontiers in physiology · 2020Review
- The effects of fatigue and oxidation on contractile function of intact muscle fibers and myofibrils isolated from the mouse diaphragm.Scientific reports · 2019Article
- Preconditioning contractions prevent the delayed onset of myofibrillar dysfunction after damaging eccentric contractions.The Journal of physiology · 2018Article
- The sag response in human muscle contraction.European journal of applied physiology · 2018Article
- Mechanical isolation, and measurement of force and myoplasmic free [CaNature protocols · 2017Article
- Phosphate increase during fatigue affects crossbridge kinetics in intact mouse muscle at physiological temperature.The Journal of physiology · 2017Article
- Mechanism of force enhancement during stretching of skeletal muscle fibres investigated by high time-resolved stiffness measurements.Journal of muscle research and cell motility · 2013Article
- Effect of temperature on crossbridge force changes during fatigue and recovery in intact mouse muscle fibers.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue occurring during exercise can be defined as the inability to maintain the initial force or power output. As fatigue becomes pronounced, force and maximum velocity of shortening are greatly reduced and force relaxation is prolonged. In principle, force loss during fatigue can result from a decrease in the number of cross-bridges generating force or a decrease of the individual cross-bridge force or to both mechanisms. The present experiments were made to investigate this point in single fibres or small fibre bundles isolated from flexor digitorum brevis (FDB) of C57BL/6 mice at 22-24◦C. During a series of 105 tetanic contractions, we measured force and fibre stiffness by applying small sinusoidal length oscillations at 2.5 or 4 kHz frequency to the activated preparation and measuring the resulting force changes. Stiffness data were corrected for the influence of compliance in series with the cross-bridge ensemble. The results show that the force decline during the first 20 tetani is due to the reduction of force developed by the individual cross-bridges and thereafter as fatigue becomes more severe, the number of cross-bridges decreases. In spite of the force reduction in the early phase of fatigue, there was an increased rate of tetanic force development and relaxation. In the latter stages of fatigue, the rate of force development and relaxation became slower. Thus, the start of fatigue is characterised by decreased cross-bridge force development and as fatigue becomes more marked, the number of cross-bridges decreases. These findings are discussed in the context of the current hypotheses about fatigue mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.