ArticleProceedings of the National Academy of Sciences of the United States of America1990
Release of peptide cotransmitters from a cholinergic motor neuron under physiological conditions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 100 citations in OpenAlex.
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- Convergent effects of peptides on the initiation of feeding motor programs in the molluskJournal of neurophysiology · 2025Article
- The Distribution and Possible Roles of Small Cardioactive Peptide in the NudibranchIntegrative organismal biology (Oxford, England) · 2020Article
- Multifaceted Expression of Peptidergic Modulation in the Feeding System of Aplysia.ACS chemical neuroscience · 2018Review
- Peptide Cotransmitters as Dynamic, Intrinsic Modulators of Network Activity.Frontiers in neural circuits · 2018Review
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- Motor neuronal activity varies least among individuals when it matters most for behavior.Journal of neurophysiology · 2015Article
- Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Neural control of unloaded leg posture and of leg swing in stick insect, cockroach, and mouse differs from that in larger animals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Variability of motor neuron spike timing maintains and shapes contractions of the accessory radula closer muscle of Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Temperature compensation of neuromuscular modulation in aplysia.Journal of neurophysiology · 2005Article
- Variability of swallowing performance in intact, freely feeding aplysia.Journal of neurophysiology · 2005Article
- Somatostatin inhibits thalamic network oscillations in vitro: actions on the GABAergic neurons of the reticular nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Presynaptic target of Ca2+ action on neuropeptide and acetylcholine release in Aplysia californica.The Journal of physiology · 2001Article
- Temporal pattern dependence of neuronal peptide transmitter release: models and experiments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Serotonin and the small cardioactive peptides differentially modulate two motor neurons that innervate the same muscle fibers in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- The secretion of classical and peptide cotransmitters from a single presynaptic neuron involves a synaptobrevin-like molecule.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Release of peptide cotransmitters in Aplysia: regulation and functional implications.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Costorage and corelease of modulatory peptide cotransmitters with partially antagonistic actions on the accessory radula closer muscle of Aplysia californica.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Functional organization of cotransmission systems: lessons from small nervous systems.Invertebrate neuroscience : IN · 1995Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In previous studies, we demonstrated that B15, one of the two cholinergic motor neurons of the accessory radula closer muscle of Aplysia, synthesizes two peptides, small cardioactive peptides A and B (SCPA and SCPB), that, when exogenously applied, increase the size and relaxation rate of muscle contractions elicited by motor neuron stimulation. In the present experiments, we obtained evidence that the SCPs are released under physiological conditions. Specifically, we characterized firing patterns of motor neuron B15 during normal behavior, simulated them in vitro, and demonstrated that this type of neuronal activity produces decreases in SCP levels in neuronal processes and terminals. We also obtained evidence that suggests that enough SCP is released under physiological conditions to modulate neuromuscular activity in the accessory radula closer. We demonstrated that physiological activity of neuron B15 produces significant increases in muscle cAMP levels. Furthermore, increases in the size and relaxation rate of muscle contractions can be produced by changes in stimulation parameters that are also likely to maximize effects of released endogenous SCPA and SCPB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.