ArticleBiophysical journal2011
Coordinated reversal of flagellar motors on a single Escherichia coli cell.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Correlation of CheY-P concentration and motor behavior during attractant adaptation in singleScience advances · 2026Article
- Article
- Structure and Dynamics of the Bacterial Flagellar Motor Complex.Biomolecules · 2024Review
- CheB localizes to polar receptor arrays during repellent adaptation.Science advances · 2024Article
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
- Flagellar motor remodeling during swarming requires FliL.Molecular microbiology · 2023Article
- Flagellar motor remodeling during swarming requires FliL.bioRxiv : the preprint server for biology · 2023Article
- The Chemoreceptor Sensory Adaptation System Produces Coordinated Reversals of the Flagellar Motors on an Escherichia coli Cell.Journal of bacteriology · 2022Article
- Surveying a Swarm: Experimental Techniques To Establish and Examine Bacterial Collective Motion.Applied and environmental microbiology · 2022Article
- Motility of the Zoonotic SpirocheteInternational journal of molecular sciences · 2022Review
- Bacterial cell-body rotation driven by a single flagellar motor and by a bundle.Biophysical journal · 2021Article
- Swimming Escherichia coli Cells Explore the Environment by Lévy Walk.Applied and environmental microbiology · 2021Article
- Fluctuations in Intracellular CheY-P Concentration Coordinate Reversals of Flagellar Motors inBiomolecules · 2020Article
- Allosteric Priming of E. coli CheY by the Flagellar Motor Protein FliM.Biophysical journal · 2020Article
- Implications of back-and-forth motion and powerful propulsion for spirochetal invasion.Scientific reports · 2020Article
- Investigating Flagella-Driven Motility in Escherichia coli by Applying Three Established Techniques in a Series.Journal of visualized experiments : JoVE · 2020Article
- Spirochete Flagella and Motility.Biomolecules · 2020Review
- Under Elevated c-di-GMP in Escherichia coli, YcgR Alters Flagellar Motor Bias and Speed Sequentially, with Additional Negative Control of the Flagellar Regulon via the Adaptor Protein RssB.Journal of bacteriology · 2019Article
- One Basic Blueprint, Many Different Motors.Journal of bacteriology · 2019Article
- Flagellar number governs bacterial spreading and transport efficiency.Science advances · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An Escherichia coli cell transduces extracellular stimuli sensed by chemoreceptors to the state of an intracellular signal molecule, which regulates the switching of the rotational direction of the flagellar motors from counterclockwise (CCW) to clockwise (CW) and from CW back to CCW. Here, we performed high-speed imaging of flagellar motor rotation and show that the switching of two different motors on a cell is controlled coordinatedly by an intracellular signal protein, phosphorylated CheY (CheY-P). The switching is highly coordinated with a subsecond delay between motors in clear correlation with the distance of each motor from the chemoreceptor patch localized at a cell pole, which would be explained by the diffusive motion of CheY-P molecules in the cell. The coordinated switching becomes disordered by the expression of a constitutively active CheY mutant that mimics the CW-rotation stimulating function. The coordinated switching requires CheZ, which is the phosphatase for CheY-P. Our results suggest that a transient increase and decrease in the concentration of CheY-P caused by a spontaneous burst of its production by the chemoreceptor patch followed by its dephosphorylation by CheZ, which is probably a wavelike propagation in a subsecond timescale, triggers and regulates the coordinated switching of flagellar motors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.