ArticleBiophysical journal2011
Stable and unstable lipid domains in ceramide-containing membranes.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Phospholipids impact the protective effects of HDL-mimetic nanodiscs against lipopolysaccharide-induced inflammation.Nanomedicine (London, England) · 2023Article
- Exploring polar headgroup interactions between sphingomyelin and ceramide with infrared spectroscopy.Scientific reports · 2020Article
- Sphingolipids and lipid rafts: Novel concepts and methods of analysis.Chemistry and physics of lipids · 2018Review
- Ceramide-lipid interactions studied by MD simulations and solid-state NMR.Biochimica et biophysica acta · 2014Article
- Coexistence of probe conformations in lipid phases-a polarized fluorescence microspectroscopy study.Biophysical journal · 2013Article
- Effects of sphingomyelin headgroup size on interactions with ceramide.Biophysical journal · 2013Article
- Recruitment of a phospholipase C/sphingomyelinase into non-lamellar lipid droplets during hydrolysis of lipid bilayers.Chemistry and physics of lipids · 2013Article
- Use of X-ray scattering to aid the design and delivery of membrane-active drugs.European biophysics journal : EBJ · 2012Review
- Lipid sorting by ceramide and the consequences for membrane proteins.Biophysical journal · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We applied x-ray diffraction, calorimetry, and infrared spectroscopy to lipid mixtures of palmitoyl-oleoyl phosphatidylcholine, sphingomyelin, and ceramide. This combination of experimental techniques allowed us to probe the stability and structural properties of coexisting lipid domains without resorting to any molecular probes. In particular, we found unstable microscopic domains (compositional/phase fluctuations) in the absence of ceramide, and macroscopically separated fluid and gel phases upon addition of ceramide. We also observed phase fluctuations in the presence of ceramide within the broad phase transition regions. We compare our results with fluorescence spectroscopy data and complement the previously reported phase diagram. We also obtained electron paramagnetic resonance data to assess the possible limitations of techniques employing a single label. Our study demonstrates the necessity of applying a combination of experimental techniques to probe local/global structural and fast/slow motional properties in complex lipid mixtures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.