ReviewStem cell research & therapy2011
Neural tissue engineering using embryonic and induced pluripotent stem cells.
Review in Stem cell research & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Nanotechnology to Overcome Blood-Brain Barrier Permeability and Damage in Neurodegenerative Diseases.Pharmaceutics · 2025Review
- Function and mechanism of mesenchymal stem cells in the healing of diabetic foot wounds.Frontiers in endocrinology · 2023Review
- Combination of stem cell therapy and acupuncture to treat ischemic stroke: a prospective review.Stem cell research & therapy · 2022Review
- Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.Stem cell research & therapy · 2021Article
- Neuroectodermal stem cells: A remyelinating potential in acute compressed spinal cord injury in rat model.Journal of biosciences · 2018Article
- Fabrication of Hemin-Doped Serum Albumin-Based Fibrous Scaffolds for Neural Tissue Engineering Applications.ACS applied materials & interfaces · 2018Article
- Mechanically stable fibrin scaffolds promote viability and induce neurite outgrowth in neural aggregates derived from human induced pluripotent stem cells.Scientific reports · 2017Article
- Modeling the behavior of human induced pluripotent stem cells seeded on melt electrospun scaffolds.Journal of biological engineering · 2017Article
- Morphogenesis of human embryonic stem cells into mature neurons underWorld journal of experimental medicine · 2016Article
- Engineering personalized neural tissue using functionalized transcription factors.Neural regeneration research · 2016Article
- Functionalizing Ascl1 with Novel Intracellular Protein Delivery Technology for Promoting Neuronal Differentiation of Human Induced Pluripotent Stem Cells.Stem cell reviews and reports · 2016Article
- Induced Pluripotent Stem Cell Therapies for Cervical Spinal Cord Injury.International journal of molecular sciences · 2016Review
- Advances in regenerative therapies for spinal cord injury: a biomaterials approach.Neural regeneration research · 2015Review
- Regenerative therapies for central nervous system diseases: a biomaterials approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Review
- Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat.Stem cell research & therapy · 2013Article
- Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons.Stem cell research & therapy · 2013Article
- Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation.Stem cell research & therapy · 2013Article
- Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell-based therapeutics for traumatic brain injury.Stem cell research & therapy · 2013Article
- Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting.Stem cell research & therapy · 2012Article
- Protoplasmic astrocytes enhance the ability of neural stem cells to differentiate into neurons in vitro.PloS one · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the recent start of the first clinical trial evaluating a human embryonic stem cell-derived therapy for the treatment of acute spinal cord injury, it is important to review the current literature examining the use of embryonic stem cells for neural tissue engineering applications with a focus on diseases and disorders that affect the central nervous system. Embryonic stem cells exhibit pluripotency and thus can differentiate into any cell type found in the body, including those found in the nervous system. A range of studies have investigated how to direct the differentiation of embryonic cells into specific neural phenotypes using a variety of cues to achieve the goal of replacing diseased or damaged neural tissue. Additionally, the recent development of induced pluripotent stem cells provides an intriguing alternative to the use of human embryonic stem cell lines for these applications. This review will discuss relevant studies that have used embryonic stem cells to replicate the tissue found in the central nervous system as well as evaluate the potential of induced pluripotent stem cells for the aforementioned applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.