ArticleProceedings of the National Academy of Sciences of the United States of America1990
Erythrophagocytosis induces heat shock protein synthesis by human monocytes-macrophages.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 117 citations in OpenAlex.
- Non-canonical transcriptional regulation of heme oxygenase in Aedes aegypti.Scientific reports · 2019Article
- Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia.OncoTargets and therapy · 2016Article
- Heme oxygenase-1 dysregulation in the brain: implications for HIV-associated neurocognitive disorders.Current HIV research · 2014Review
- Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies.Journal of translational medicine · 2011Article
- Increased proteolysis of diphtheria toxin by human monocytes after heat shock: a subsidiary role for heat-shock protein 70 in antigen processing.Immunology · 2007Article
- Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse.The American journal of pathology · 2004Article
- Age-related decrease in the inducibility of heat-shock protein 70 in human peripheral blood mononuclear cells.Journal of clinical immunology · 2002Article
- Heat shock protein-27 protects human bronchial epithelial cells against oxidative stress-mediated apoptosis: possible implication in asthma.Cell stress & chaperones · 2002Article
- Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediates.The Biochemical journal · 2001Article
- Heat shock and proinflammatory stressors induce differential localization of heat shock proteins in human monocytes.Inflammation · 1997Article
- Mitochondria are selective targets for the protective effects of heat shock against oxidative injury.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Phagocytosis of Pseudomonas aeruginosa fails to elicit heat shock protein expression in human monocytes.Inflammation · 1996Article
- Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Differential induction of stress proteins and functional effects of heat shock in human phagocytes.Inflammation · 1995Article
- Induction by prostaglandin A1 of haem oxygenase in myoblastic cells: an effect independent of expression of the 70 kDa heat shock protein.The Biochemical journal · 1995Article
- Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells.The Biochemical journal · 1994Article
- Arachidonate is a potent modulator of human heat shock gene transcription.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.The American journal of pathology · 1993Article
- Phagocytosis of Staphylococcus aureus induces a selective stress response in human monocytes-macrophages (M phi): modulation by M phi differentiation and by iron.Infection and immunity · 1993Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure of cells to elevated temperatures and other environmental stresses results in the expression of specific genes encoding the so-called heat shock proteins (HSPs). Since exogenous H2O2 induces in human monocytes the synthesis of HSPs, and previous induction of HSPs protects these cells from oxidative injury, we investigated whether HSP synthesis was also induced during generation of reactive oxygen species by the phagocyte itself during phagocytosis. As a model system, we analyzed the effects of erythrophagocytosis on protein synthesis by the human premonocytic line U937, in which phagocytosis is induced during differentiation with 1,25-dihydroxyvitamin D3. Exposure to whole erythrocytes, but not to erythrocyte ghosts, induced in the phagocytic cells only the synthesis of the 70- and 83- to 90-kDa HSPs and a 32-kDa oxidation-related stress protein identical by partial peptide mapping to heme oxygenase. The radioprotective aminothiol N-(2'-mercaptoethyl)-1,3-propanediamine (WR-1065), which can substitute for glutathione as hydrogen donor, prevented this induction. These results suggest that oxygen free radicals generated in the presence of hemoglobin-derived iron and consecutive glutathione depletion are involved in induction of stress protein synthesis during erythrophagocytosis. HSPs synthesized during phagocytosis may play a role in the phagocyte's defense mechanisms and in protective immunity.
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