ArticleJournal of the American Chemical Society2011
Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Constant Temperature Electrochemical Biosensor for SNP Detection in Human Genomic DNA Based on DNA Melting Analysis.ACS sensors · 2025Article
- A Convenient Oligonucleotide Conjugation via Tandem Staudinger Reaction and Amide Bond Formation at the Internucleotidic Phosphate Position.International journal of molecular sciences · 2024Article
- Non-terminal conjugation of small interfering RNAs with spermine improves duplex binding and serum stability with position-specific incorporation.RSC advances · 2023Article
- Zip Nucleic Acid-Based Genomagnetic Assay for Electrochemical Detection of microRNA-34a.Biosensors · 2023Article
- DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Synthetic Approaches for Copolymers Containing Nucleic Acids and Analogues: Challenges and Opportunities.Polymer chemistry · 2021Article
- Synthesis of siRNAs incorporated with cationic peptides R8G7 and R8A7 and the effect of the modifications on siRNA properties.RSC advances · 2020Article
- Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.Molecular therapy. Nucleic acids · 2018Article
- Enhanced Intercellular Delivery of cRGD-siRNA Conjugates by an Additional Oligospermine Modification.ACS omega · 2018Article
- Self-neutralizing oligonucleotides with enhanced cellular uptake.Organic & biomolecular chemistry · 2017Article
- Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.The Journal of clinical investigation · 2016Article
- Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.Annual review of pharmacology and toxicology · 2016Review
- Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis.Organic & biomolecular chemistry · 2014Article
- Oligonucleotide-based strategies to combat polyglutamine diseases.Nucleic acids research · 2014Review
- Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.Nucleic acids research · 2013Article
- Article
- Allele-selective inhibition of trinucleotide repeat genes.Drug discovery today · 2012Review
- Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system.International journal of nanomedicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Oligonucleotides and their derivatives are a proven chemical strategy for modulating gene expression. However, their negative charge remains a challenge for delivery and target recognition inside cells. Here we show that oligonucleotide-oligospermine conjugates (Zip nucleic acids or ZNAs) can help overcome these shortcomings by serving as effective antisense and antigene agents. Conjugates containing DNA and locked nucleic acid (LNA) oligonucleotides are active, and oligospermine conjugation facilitates carrier-free cell uptake at nanomolar concentrations. Conjugates targeting the CAG triplet repeat within huntingtin (HTT) mRNA selectively inhibit expression of the mutant huntingtin protein. Conjugates targeting the promoter of the progesterone receptor (PR) function as antigene agents to block PR expression. These observations support further investigation of ZNA conjugates as gene silencing agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.