ArticleJournal of natural products2011
Cryptocaryols A-H, α-pyrone-containing 1,3-polyols from Cryptocarya sp. implicated in stabilizing the tumor suppressor Pdcd4.
Article in Journal of natural products, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Keck asymmetric allylation in natural product synthesis: applications and developments (2018-2026).RSC advances · 2026Review
- Gonystylones A-E, Antiproliferative 5,6-Dihydro-α-pyrones from the PlantJournal of natural products · 2026Article
- Bioactive Properties ofPlants (Basel, Switzerland) · 2024Article
- Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M fromJournal of natural products · 2019Article
- Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.Organic letters · 2018Article
- Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation.Angewandte Chemie (International ed. in English) · 2016Article
- Article
- Antimalarial 5,6-Dihydro-α-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-α-Pyrones Are Artifacts1.Journal of natural products · 2015Article
- Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.Marine drugs · 2014Article
- Cryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4.ACS medicinal chemistry letters · 2014Article
- Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.Biochemical pharmacology · 2014Article
- Cryptocaryols A and B: total syntheses, stereochemical revision, structure elucidation, and structure-activity relationship.Journal of the American Chemical Society · 2013Article
- Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A high-throughput cell-based reporter assay designed to identify small-molecule stabilizers of the tumor suppressor Pdcd4 was used to screen extracts in the NCI Natural Products Repository. Bioassay-guided fractionation of an extract from a Papua New Guinea collection of the tropical tree Cryptocarya sp. provided a series of new 5,6-dihydro-α-pyrone-containing 1,3-polyols (1-8), named cryptocaryols A-H. Their structures were assigned from a combination of NMR, MS, and CD studies in conjunction with NMR database comparisons. Compounds 1-8 were found to rescue Pdcd4 from TPA-induced degradation with EC50 concentrations that ranged from 1.3 to 4.9 μM.
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