ArticleGenesis (New York, N.Y. : 2000)2011
In vivo labeling of zebrafish motor neurons using an mnx1 enhancer and Gal4/UAS.
Article in Genesis (New York, N.Y. : 2000), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 69 citations in OpenAlex.
- WASHC3 knockout disrupts mitochondrial protein homeostasis and energy metabolism in cardiomyocytes.Frontiers in cardiovascular medicine · 2026Article
- Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission.iScience · 2024Article
- Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- TUBA4A downregulation as observed in ALSFrontiers in cellular neuroscience · 2024Article
- Transgenic expression in zebrafish embryos with an intact chorion by electroporation and microinjection.Biotechnology reports (Amsterdam, Netherlands) · 2023Article
- Article
- Ciliary localization of a light-activated neuronal GPCR shapes behavior.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Investigating Neuron Degeneration in Huntington's Disease Using RNA-Seq Based Transcriptome Study.Genes · 2023Article
- Zebrafish as a model organism for neurodegenerative disease.Frontiers in molecular neuroscience · 2022Review
- Optogenetic axon guidance in embryonic zebrafish.STAR protocols · 2021Article
- Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration.Nature communications · 2021Article
- Non-Rodent Genetic Animal Models for Studying Tauopathy: Review ofInternational journal of molecular sciences · 2021Review
- Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.Scientific reports · 2021Article
- Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish.The FEBS journal · 2021Article
- Illuminating ALS Motor Neurons With Optogenetics in Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord.Science (New York, N.Y.) · 2020Article
- Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness.Human molecular genetics · 2020Article
- Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects.Developmental cell · 2020Article
- The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish.Frontiers in molecular neuroscience · 2020Article
- Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin.Frontiers in neuroanatomy · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The zebrafish spinal cord primary motor neurons are commonly used as an experimental model to study the molecular mechanisms that regulate axonal pathfinding and neuromuscular junction formation, and for the modeling of human neurodegenerative disorders. This study characterized a 125-bp mnx1 enhancer to direct gene expression in spinal cord motor neurons. A promoter containing three copies of the 125-bp mnx1 enhancer was generated in a Tol2 vector and used to drive enhanced green fluorescent protein (EGFP) expression either directly or in combination with the Gal4/UAS transcriptional activation system. Both methods induced protein expression for up to 5 days after fertilization, allowing the observation of the dendritic tree and axonal arborization of single motor neurons within a somitic segment in fixed and live animals. The use of the 125-bp mnx1 promoter for transient transgenic expression or for the generation of stable transgenic fish lines will facilitate the study of motor neuron development and neurodegenerative processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.