ArticleSynapse (New York, N.Y.)2011
Recombinant human immunodeficiency virus-1 transactivator of transcription1-86 allosterically modulates dopamine transporter activity.
Abstract readComparative Study
In one paragraph
Article in Synapse (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 53 citations in OpenAlex.
- Neonatal intrahippocampal HIV-1 protein Tat(1-86) injection: neurobehavioral alterations in the absence of increased inflammatory cytokine activation.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Trial
- EcoHIV Infection Disrupts Dopamine and Serotonin Transporter Function, Altering Release Dynamics in C57BL/6J Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- Synthesis and evaluation of novel substituted N-(2-phenylbutyl)-5,6,7,8-tetrahydro-quinazolin-4-amines as allosteric modulators of HIV-DAT-tat interaction.Bioorganic & medicinal chemistry letters · 2025Article
- Mutational effects of the asparagine198 and glutamate223 residues on the human norepinephrine transporter on basal and HIV-1 Tat protein-induced inhibition of dopamine transport.European journal of pharmacology · 2025Article
- Exploring new frontiers in the treatment of HIV-associated neurocognitive disorder.The Journal of pharmacology and experimental therapeutics · 2025Article
- Novel Allosteric Modulator Southern Research Institute-32743 Reverses HIV-1 Transactivator of Transcription-Induced Increase in Dopamine Release in the Caudate Putamen of Inducible Transactivator of Transcription Transgenic Mice.The Journal of pharmacology and experimental therapeutics · 2023Article
- Overview of the structure and function of the dopamine transporter and its protein interactions.Frontiers in physiology · 2023Review
- iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression.Pharmacology, biochemistry, and behavior · 2023Article
- Review
- Article
- Substance abuse and neurotransmission.Advances in pharmacology (San Diego, Calif.) · 2022Article
- Mutations of Human DopamineTransporter at Tyrosine88, Aspartic Acid206, and Histidine547 Influence Basal and HIV-1 Tat-inhibited Dopamine Transport.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat.Frontiers in neurology · 2021Article
- [The Journal of pharmacology and experimental therapeutics · 2020Article
- Male HIV-1 transgenic rats show reduced cocaine-maintained lever-pressing compared to F344 wildtype rats despite similar baseline locomotion.Journal of the experimental analysis of behavior · 2020Article
- Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults.Brain research · 2019Review
- Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport.Scientific reports · 2019Article
- Scaling Synapses in the Presence of HIV.Neurochemical research · 2019Review
- Dose-dependent neurocognitive deficits following postnatal day 10 HIV-1 viral protein exposure: Relationship to hippocampal anatomy parameters.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Article
- The role of human dopamine transporter in NeuroAIDS.Pharmacology & therapeutics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Jun ZhuDepartment of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, South Carolina, USA. zhuj@sccp.sc.edu
Subramaniam Ananthan
Charles F Mactutus
Rosemarie M Booze
University of South Carolina · USSouthern Research Institute · US
Funding
HIV/COCAINE NEUROTOXICITY IN FEMALESR01DA013137 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOOZE, ROSEMARIE M, MACTUTUS, CHARLES F. · 2000 to 2021
$7.7MMaternal HIV: Developmental Neurotoxicity - Administrative SupplementR01HD043680 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BOOZE, ROSEMARIE M, MACTUTUS, CHARLES F. · 2003 to 2016
$2.8MTargeted Library Synthesis and Screening: Allosteric Modulators of TransportersR33DA029962 · NIDA · SOUTHERN RESEARCH INSTITUTE · PI ANANTHAN, SUBRAMANIAM · 2012 to 2014
$1.2MTargeted Library Synthesis and Screening: Allosteric Modulators of TransportersR21DA029962 · NIDA · SOUTHERN RESEARCH INSTITUTE · PI ANANTHAN, SUBRAMANIAM · 2010 to 2011
$757kMethamphetamine and HIV-1: NMDAR/D1 mediated neurologic effectsR03DA031604 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MACTUTUS, CHARLES F. · 2011 to 2012
$290kRole of Dopamine Transporter: HIV-1 Tat Protein and Nicotine SensitizationR03DA026721 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ZHU, JUN · 2009 to 2010
$287kRole of DARPP-32: Individual Responsiveness to NicotineR03DA024275 · NIDA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ZHU, JUN · 2009 to 2010
$144kNICHD NIH HHS R01 HD043680NIDA NIH HHS DA013137NIDA NIH HHS DA024275NIDA NIH HHS DA026721NIDA NIH HHS R01 DA013137NIDA NIH HHS R03 DA024275NIDA NIH HHS R03 DA026721NIDA NIH HHS R03 DA031604NIDA NIH HHS R21 DA029962
Abstract
PubMed holds no abstract for this paper.
Indexed as
Allosteric RegulationAnimalsDopamine Plasma Membrane Transport ProteinsHIV-1HumansMalePeptide FragmentsRatsRats, Sprague-DawleyRecombinant Proteinstat Gene Products, Human Immunodeficiency VirusTranscriptional ActivationUp-RegulationDopamine Plasma Membrane Transport ProteinsPeptide FragmentsRecombinant Proteinstat Gene Products, Human Immunodeficiency Virus
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.