ArticleMovement disorders : official journal of the Movement Disorder Society2011
Reward processing abnormalities in Parkinson's disease.
Article in Movement disorders : official journal of the Movement Disorder Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Microstructural correlates of olfactory dysfunction in Parkinson's Disease: a systematic review of diffusion MRI studies.Brain imaging and behavior · 2025Pooled it
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- Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features.Frontiers in molecular neuroscience · 2024Article
- Betting on Non-Invasive Brain Stimulation to Treat Gambling Disorder: A Systematic Review and Meta-Analysis.Brain sciences · 2023Review
- Endogenous dopamine transmission is crucial for motor skill recovery after stroke.IBRO neuroscience reports · 2022Article
- Characterization of D3 Autoreceptor Function in Whole Zebrafish Brain with Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2022Article
- Resilience in People with Lewy Body Disorders and Their Care Partners: Association with Mental Health, Relationship Satisfaction, and Care Burden.Brain sciences · 2022Article
- Motor cortex modulation and reward in children with attention-deficit/hyperactivity disorder.Brain communications · 2021Article
- Altruistic Punishment and Impulsivity in Parkinson's Disease: A Social Neuroscience Perspective.Frontiers in behavioral neuroscience · 2020Article
- Dopaminergic influences on risk preferences of Parkinson's disease patients.Cognitive, affective & behavioral neuroscience · 2019Article
- Changes in Magnitude and Variability of Corticospinal Excitability During Rewarded Time-Sensitive Behavior.Frontiers in behavioral neuroscience · 2019Article
- Nonequivalent modulation of corticospinal excitability by positive and negative outcomes.Brain and behavior · 2018Article
- Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.Neuropharmacology · 2017Article
- Modulation of corticospinal excitability by reward depends on task framing.Neuropsychologia · 2015Article
- Association of COMT val158met and DRD2 G>T genetic polymorphisms with individual differences in motor learning and performance in female young adults.Journal of neurophysiology · 2014Article
- Gambling disorder during dopamine replacement treatment in Parkinson's disease: a comprehensive review.BioMed research international · 2014Review
- Decision and dopaminergic system: an ERPs study of Iowa gambling task in Parkinson's disease.Frontiers in psychology · 2014Article
- Motor cortex-evoked activity in reciprocal muscles is modulated by reward probability.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The primary motor cortex is important for motor learning and response selection, functions that require information on the expected and actual outcomes of behavior. Therefore, it should receive signals related to reward. Pathways from reward centers to motor cortex exist in primates. Previously, we showed that gamma aminobutyric acid-A-mediated inhibition in the motor cortex, measured by paired transcranial magnetic stimulation, changes with expectation and uncertainty of money rewards generated by a slot machine simulation. We examined the role of dopamine in this phenomenon by testing 13 mildly affected patients with Parkinson's disease, off and on dopaminergic medications, and 13 healthy, age-matched controls. Consistent with a dopaminergic mechanism, reward expectation or predictability modulated the response to paired transcranial magnetic stimulation in controls, but not in unmedicated patients. A single dose of pramipexole restored this effect of reward, mainly by increasing the paired transcranial magnetic stimulation response amplitude during low expectation. Levodopa produced no such effect. Both pramipexole and levodopa increased risk-taking behavior on the Iowa Gambling Task. However, pramipexole increased risk-taking behavior more in patients showing lower paired transcranial magnetic stimulation response amplitude during low expectation. These results provide evidence that modulation of motor cortex inhibition by reward is mediated by dopamine signaling and that the physiological state of the motor cortex changes with risk-taking tendency in patients on pramipexole. The cortical response to reward expectation may represent an endophenotype for risk-taking behavior in patients on agonist treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.