Evidence map›Paper›PMID 21538511›Full record

ReviewJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011

A clinician's guide to X-linked hypophosphatemia.

Thomas O Carpenter, Erik A Imel, Ingrid A Holm, Suzanne M Jan de Beur, Karl L Insogna

Erratum issued Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03348644 (Milk Products in the Treatment of Hypophosphatemic Rickets), which is not on this map. Cited by 309 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
309citing papers in PubMed, 6 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03348644 nacompletednot on this mapstarted 2015, after this paper: background citation

Milk Products in the Treatment of Hypophosphatemic Rickets: A Randomised Crossover Trial

TypeinterventionalSponsorUniversity of AarhusRan2015 to 2016Enrolled7ConditionsHypophosphatemic RicketsArmsPhosphate tablets., High cheese intake., High milk intake.
3 · Its place in the literature

Who cites it

309 citing papers in PubMed, 6 syntheses or guidelines pooled it, 599 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Burden of disease associated with X-linked hypophosphataemia in adults: a systematic literature review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  18. Article
  19. Article
  20. Real-world impact of treatment on growth in children with X-linked hypophosphatemia.The Journal of clinical endocrinology and metabolism · 2026
    Observational

249 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Thomas O CarpenterDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8064, USA. Thomas.carpenter@yale.edu
Erik A Imel
Ingrid A Holm
Suzanne M Jan de Beur
Karl L Insogna
Yale University · USHarvard University · USIndiana University School of MedicineJohns Hopkins University · US

Funding

Research Core: Biochemistry and histology/histomorphometryP50AR054086 · NIAMS · YALE UNIVERSITY · PI CARPENTER, THOMAS O · 2006 to 2010
$8.5M
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.K23AR057096 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI IMEL, ERIK ALLEN · 2009 to 2013
$642k
NIAMS NIH HHS 1K23AR057096NIAMS NIH HHS K23 AR057096NIAMS NIH HHS L40 AR056526NIAMS NIH HHS P50 AR054086
6 · The paper itself

Abstract

X-linked hypophosphatemia (XLH) is the prototypic disorder of renal phosphate wasting, and the most common form of heritable rickets. Physicians, patients, and support groups have all expressed concerns about the dearth of information about this disease and the lack of treatment guidelines, which frequently lead to missed diagnoses or mismanagement. This perspective addresses the recommendation by conferees for the dissemination of concise and accessible treatment guidelines for clinicians arising from the Advances in Rare Bone Diseases Scientific Conference held at the NIH in October 2008. We briefly review the clinical and pathophysiologic features of the disorder and offer this guide in response to the conference recommendation, based on our collective accumulated experience in the management of this complex disorder.

Indexed as

Familial Hypophosphatemic RicketsGenetic Diseases, X-LinkedHumansPractice Guidelines as TopicRadiography

Identifiers

PMID21538511
PMCPMC3157040
OpenAlexW1985742682

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.