ArticleHepatology (Baltimore, Md.)2011
Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice.
Article in Hepatology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
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- Albumin promoter-driven FlpO expression induces efficient genetic recombination in mouse liver.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- MYC determines lineage commitment in KRAS-driven primary liver cancer development.Journal of hepatology · 2023Article
- Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish.iScience · 2021Article
- Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.Antioxidants (Basel, Switzerland) · 2021Article
- YAP-Dependent Induction of CD47-Enriched Extracellular Vesicles Inhibits Dendritic Cell Activation and Ameliorates Hepatic Ischemia-Reperfusion Injury.Oxidative medicine and cellular longevity · 2021Article
- NADPH-dependent and -independent disulfide reductase systems.Free radical biology & medicine · 2018Review
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- How does the tumor microenvironment play a role in hepatobiliary tumors?Journal of gastrointestinal oncology · 2018Review
- Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.Hepatology (Baltimore, Md.) · 2016Article
- Lineage fate of ductular reactions in liver injury and carcinogenesis.The Journal of clinical investigation · 2015Article
- Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver.Nature communications · 2015Article
- Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury.Hepatology (Baltimore, Md.) · 2014Article
- Dual fluorescent reporter pig for Cre recombination: transgene placement at the ROSA26 locus.PloS one · 2014Article
- Hydrodynamic delivery of Cre protein to lineage-mark or time-stamp mouse hepatocytes in situ.PloS one · 2014Article
- Nuclear double-fluorescent reporter for in vivo and ex vivo analyses of biological transitions in mouse nuclei.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Sox9 and programming of liver and pancreatic progenitors.The Journal of clinical investigation · 2013Review
- FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.Genes & development · 2013Article
- Clinical data and characterization of the liver conditional mouse model exclude neoplasia as a non-neurological manifestation associated with Friedreich's ataxia.Disease models & mechanisms · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledThe contributions that de novo differentiation of new hepatocyte lineages makes to normal liver physiology are unknown. In this study, a system that uniquely marks cells during a finite period following primary activation of a serum albumin gene promoter/enhancer-driven Cre recombinase (albCre) transgene was used to investigate birthrates of new hepatocyte lineages from albumin (Alb)-naive precursors in mice. Elapsed time was measured with a two-color fluorescent marker gene that converts from expressing tandem dimer Tomato (tdT; a red fluorescent protein) to expressing green fluorescent protein (GFP) following primary exposure to Cre. The accumulation of GFP and the decay of tdT each contributed to a regular fluorescence transition, which was calibrated in vivo. In normal adults, this system revealed that a steady-state level of 0.076% of all hepatocytes had differentiated within the previous 4 days from albCre-naive cell lineages. In comparison with resting adult livers, the relative abundance of these newborn hepatocytes was elevated 3.7-fold in the growing livers of juveniles and 8.6-fold during liver regeneration after partial hepatectomy in adults.
conclusionNewborn hepatocyte lineages arising from Alb-naive cells contribute to liver maintenance under normal conditions. Hepatocyte lineage birthrates can vary in response to the liver's physiological status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.