ReviewSeminars in liver disease2011
Genomics in the post-GWAS era.
Review in Seminars in liver disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Using GWAS and Machine Learning to Identify and Predict Genetic Variants Associated with Foodborne Bacteria Phenotypic Traits.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Identification of Missense Variants Affecting Carcass Traits for Hanwoo Precision Breeding.Genes · 2023Article
- Novel EDGE encoding method enhances ability to identify genetic interactions.PLoS genetics · 2021Article
- Understanding polygenic models, their development and the potential application of polygenic scores in healthcare.Journal of medical genetics · 2020Review
- Functional annotation of melanoma risk loci identifies novel susceptibility genes.Carcinogenesis · 2020Article
- Genetics of COPD.Annual review of physiology · 2020Review
- Hhip haploinsufficiency sensitizes mice to age-related emphysema.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genome-Wide Association Studies in Primary Biliary Cirrhosis.Seminars in liver disease · 2015Review
- Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation.PloS one · 2015Article
- Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle.BMC genomics · 2014Article
- Genome-wide association studies on prostate cancer: the end or the beginning?Protein & cell · 2013Review
- Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations.American journal of human genetics · 2013Article
- The genetics of complex cholestatic disorders.Gastroenterology · 2013Review
- Systems genetics in "-omics" era: current and future development.Theory in biosciences = Theorie in den Biowissenschaften · 2013Review
- The genomic signature of trait-associated variants.BMC genomics · 2013Article
- The PhenX Toolkit pregnancy and birth collections.Annals of epidemiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The field of genomics has entered a new era in which the ability to identify genetic variants that impact complex human traits and disease in an unbiased fashion using genome-wide approaches is widely accessible. To date, the workhorse of these efforts has been the genome-wide association study (GWAS), which has quickly moved from novel to routine, and has provided key insights into aspects of the underlying allelic architecture of complex traits. The main lesson learned from the early GWAS efforts is that though many disease-associated variants are often discovered, most have only a minor effect on disease, and in total explain only a small amount of the apparent heritability. Here we provide a brief overview of the genetic variation classes that may harbor the heritability missing from GWAS, and touch on approaches that will be leveraged in the coming years as genomics-and by extension medicine-becomes increasingly personalized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.