Evidence map›Paper›PMID 21538253›Full record

ArticleJournal of microbiology (Seoul, Korea)2011

The Helicobacter pylori Ferric Uptake Regulator (Fur) is essential for growth under sodium chloride stress.

Hanan Gancz, D Scott Merrell

Open access · greenAbstract read
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. A Positively SelectedInfection and immunity · 2023
    Article
  3. Insights into the Orchestration of Gene Transcription Regulators inInternational journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hanan GanczDepartment of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
D Scott Merrell
Uniformed Services University of the Health Sciences · US

Funding

Regulatory Networks of Helicobacter pyloriR01AI065529 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MERRELL, D. SCOTT · 2007 to 2011
$1.9M
Regulatory Mechanisms of Helicobacter pyloriR56AI065529 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI MERRELL, D. SCOTT · 2013 to 2013
$357k
NIAID NIH HHS AI065529NIAID NIH HHS R01 AI065529NIAID NIH HHS R56 AI065529
6 · The paper itself

Abstract

Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.

Indexed as

Osmotic PressureBacterial ProteinsGene Expression ProfilingGene Knockout TechniquesHelicobacter pyloriRepressor ProteinsSodium ChlorideBacterial Proteinsferric uptake regulating proteins, bacterialRepressor ProteinsSodium Chloride

Identifiers

PMID21538253
PMCPMC3125944
OpenAlexW2172177565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.