ArticleJournal of neurology2011
Evaluation of contributing factors to restless legs syndrome in migraine patients.
Article in Journal of neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Role of vitamins in the pathogenesis and treatment of restless leg syndrome: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Migraine and sleep disorders: a systematic review.The journal of headache and pain · 2020Pooled it
- Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Restless legs syndrome associated with major diseases: A systematic review and new concept.Neurology · 2016Pooled it
- Migraine and restless legs syndrome in women.Cephalalgia : an international journal of headache · 2012Trial
- Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review.Journal of clinical medicine · 2026Review
- Bridging Gaps in Migraine Management: A Comprehensive Review of Conventional Treatments, Natural Supplements, Complementary Therapies, and Lifestyle Modifications.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Clinical impact of restless legs syndrome in patients with migraine: a 12-year, single-center, longitudinal study.Sleep and biological rhythms · 2025Article
- Associations between the burdens of comorbid sleep problems, central sensitization, and headache-related disability in patients with migraine.Frontiers in neurology · 2024Article
- Comorbidities in patients with migraine in Japan: a cross-sectional study using data from National Health and Wellness Survey.BMJ open · 2022Article
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D.Frontiers in neurology · 2021Article
- Association of genetic variants in migraineurs with and without restless legs syndrome.Annals of clinical and translational neurology · 2020Article
- Restless legs syndrome and tension-type headache: a population-based study.The journal of headache and pain · 2017Article
- The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study.The journal of headache and pain · 2017Article
- Sleep Quality and Depression and Their Association with Other Factors in Hemodialysis Patients.Global journal of health science · 2016Article
- Relationship between primary restless legs syndrome and migraine with aura.The Kaohsiung journal of medical sciences · 2016Article
- Increased Risk of Restless Legs Syndrome in Patients With Migraine: A Nationwide Population-Based Cohort Study.Medicine · 2016Article
- Migraine and restless legs syndrome are associated in adults under age fifty but not in adults over fifty: a population-based study.The journal of headache and pain · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have provided evidence for a positive association between migraine and restless legs syndrome (RLS), although the exact mechanisms and contributing factors remain unclear. A cross-sectional, case-control study was conducted, including patients with migraine (n = 262) and headache-free control subjects (n = 163). Migraine was diagnosed according to International Classification of Headache Disorders II criteria. RLS diagnosis was made based on four essential criteria as described by the International Restless Legs Syndrome Study Group. All patients completed the Migraine Disability Assessment (MIDAS) questionnaire, Beck Depression Inventory (BDI)-II scores, Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). A total of 210 blood samples were collected to correlate various parameters with RLS. RLS frequency was significantly greater in patients with migraine than in controls (13.7 vs. 1.8%). Migraine patients with RLS had high scores for MIDAS, BDI-II, PSQI, and ESS compared with those without RLS. In addition, migraine patients with RLS had a high rate of smoking and RLS family history, as well as increased levels of serum phosphorus and urea nitrogen compared with those without RLS. However, there was no difference in serum iron and ferritin levels between the groups. In migraine patients, logistic regression analysis revealed that positive RLS family history, BDI-II, ESS, and serum phosphorus levels were significant RLS predictors. Our study confirmed a positive association between RLS and migraine. RLS comorbidity in migraine patients was associated with insomnia, daytime sleepiness, depressive symptoms, headache-related disability, and increased serum phosphorus levels. These findings may provide a better understanding of RLS pathogenesis in migraine.
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Registered trials
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