Trial reportClinical oral investigations2012
Long-term oral appliance therapy in obstructive sleep apnea syndrome: a controlled study on temporomandibular side effects.
Trial report in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 7 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Oral appliances for obstructive sleep apnoea in adults.The Cochrane database of systematic reviews · 2026Pooled it
- Comparison of side effects of different mandibular advancement devices for patients with obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Pooled it
- Effect of mandibular advancement appliance use on oral and periodontal health in patients with OSA: a systematic review.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2021Guideline
- Side effects of mandibular advancement splints for the treatment of snoring and obstructive sleep apnea: a systematic review.Dental press journal of orthodontics · 2018Pooled it
- The effectiveness of different mandibular advancement amounts in OSA patients: a systematic review and meta-regression analysis.Sleep & breathing = Schlaf & Atmung · 2016Pooled it
- Clinical Practice Guideline for the Treatment of Obstructive Sleep Apnea and Snoring with Oral Appliance Therapy: An Update for 2015.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Trial
- A stepwise titration protocol for oral appliance therapy in positional obstructive sleep apnea patients: proof of concept.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: A randomized, placebo-controlled trial on temporomandibular side-effects.Clinical and experimental dental research · 2020Trial
- Durability of treatment effects of the Sleep Position Trainer versus oral appliance therapy in positional OSA: 12-month follow-up of a randomized controlled trial.Sleep & breathing = Schlaf & Atmung · 2018Trial
- Trial
- Long-term oral appliance therapy in obstructive sleep apnea syndrome: a controlled study on dental side effects.Clinical oral investigations · 2013Trial
- Mandibular Advancement Device Therapy in 182 DISE-Selected Adults with Moderate-to-Severe Obstructive Sleep Apnea: A Multicenter Real-World Study.Biomedicines · 2026Article
- Article
- Prevalence of Temporomandibular Disorders in Obstructive Sleep Apnea Patients and Relationship Between Temporomandibular Disorder Phenotypes and Severity of Sleep Apnea: An Observational Study.Journal of pharmacy & bioallied sciences · 2025Article
- Advancing Obstructive Sleep Apnea Management: Recent Trends from Conventional to Innovative Therapies.Journal of clinical medicine · 2025Review
- Objectively measured adherence may affect side effects of mandibular advancement therapy in subjects with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Obstructive sleep apnea treatment improves temporomandibular disorder pain.Sleep & breathing = Schlaf & Atmung · 2024Article
- Comparison of Pre- and Posttreatment Airway Volume in Patients with Temporomandibular Joint Disorders Treated with Ultra-Low Frequency Transcutaneous Electrical Nerve Stimulation Using Cone Beam Computed Tomography.International archives of otorhinolaryngology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to assess variations in the occurrence of temporomandibular disorders (TMDs) and the risk of developing pain and function impairment of the temporomandibular complex in obstructive sleep apnea syndrome (OSAS) patients treated with either an oral appliance (mandibular advancement device) or continuous positive airway pressure (CPAP) in a 2-year follow-up study. In addition, we assessed the relationship between the mean mandibular protrusion and the frequency of wearing the appliance during follow-up with the occurrence of pain and function impairment of the temporomandibular complex. Fifty-one patients were randomized to oral appliance therapy and 52 patients to CPAP therapy. TMDs (diagnosed according to the Axis I Research Diagnostic Criteria for TMD), pain intensity and disability and mandibular function impairment were recorded at baseline, after 2 months, 1 year and 2 years of therapy. Only in the initial period of treatment the occurrence of pain-related TMDs was considerably higher (24%) in the oral appliance group compared to CPAP (6%). Oral appliance therapy furthermore resulted in more temporomandibular pain compared to CPAP (odds ratio 2.33, 95% confidence interval (1.22-4.43)). However, there were no limitations in mandibular function in both groups during the (entire) follow-up period. Although generally not serious and of transient nature, oral appliance therapy results in more pain-related TMDs in the initial period of use compared with CPAP therapy. Oral appliance therapy is associated with increased pain in the temporomandibular complex in the initial period of use. Because of the transient nature, this pain is not a reason to contra-indicate an oral appliance in OSAS patients. Moreover, TMDs and the risk of developing pain and function impairment of the temporomandibular complex appear limited with long-term oral appliance use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.