ArticleCellular oncology (Dordrecht, Netherlands)2011
The survivin -31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival.
Article in Cellular oncology (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis.World journal of surgical oncology · 2015Pooled it
- Survivin rs9904341 (G>C) polymorphism contributes to cancer risk: an updated meta-analysis of 26 studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association between survivin -31G>C polymorphism and cancer risk: meta-analysis of 29 studies.Journal of cancer research and clinical oncology · 2014Pooled it
- Pooled it
- Combined Inhibition ofInternational journal of molecular sciences · 2023Article
- Characterization and clustering of kinase isoform expression in metastatic melanoma.PLoS computational biology · 2022Article
- NF-κB2 and RELB offer prognostic information in colorectal cancer and NFKB2 rs7897947 represents a genetic risk factor for disease development.Translational oncology · 2021Article
- Evaluation of immunohistochemical expression of survivin and its correlation with -31G/C gene polymorphism in colorectal cancer.Medical molecular morphology · 2019Article
- Survivin at a glance.Journal of cell science · 2019Review
- Survivin expression in canine spontaneous cutaneous and subcutaneous tumors and its prognostic importance.Veterinary world · 2017Article
- Article
- Technical reproducibility of single-nucleotide and size-based DNA biomarker assessment using DNA extracted from formalin-fixed, paraffin-embedded tissues.The Journal of molecular diagnostics : JMD · 2015Article
- Survivin: A molecular biomarker in cancer.The Indian journal of medical research · 2015Review
- Survivin -31 G/C polymorphism might contribute to colorectal cancer (CRC) risk: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer.Cancer cell international · 2014Article
- Clinico-pathologic relevance of Survivin splice variant expression in cancer.Cancer letters · 2013Review
- Polymorphisms of survivin and its protein expression are associated with colorectal cancer susceptibility in Chinese population.DNA and cell biology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurvivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. Moreover, the 9386 C/T and -31 G/C polymorphisms were investigated.
methodsQuantitative RT-PCR was used to assess mRNA levels in fresh/frozen tissue samples. Protein levels were immunohistochemically evaluated on formalin-fixed paraffin-embedded tissue sections. Individuals were genotyped using real time PCR.
resultsExpression of all 5 survivin splice variants as well as survivin protein was elevated in colorectal carcinomas compared to normal tissue. Specific splice variant expression differentially correlated with clinicopathological parameters. Furthermore, both snps correlated with splice variant levels or their ratios in colorectal carcinomas while the -31 G/C snp may be related to CRC development and improved overall survival.
conclusionOur results support a role of survivin in colorectal carcinogenesis while the -31 G/C snp may constitute a marker of survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.