ArticleWorld journal of diabetes2010
Latent autoimmune diabetes in adults: A distinct but heterogeneous clinical entity.
Article in World journal of diabetes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Bariatric Surgery in Type 1 Diabetes Mellitus: A Systematic Review.Obesity surgery · 2016Pooled it
- Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Low rate of latent autoimmune diabetes in adults (LADA) in patients followed for type 2 diabetes: A single center's experience in Turkey.Archives of endocrinology and metabolism · 2021Article
- Adapting Medication for Type 2 Diabetes to a Low Carbohydrate Diet.Frontiers in nutrition · 2021Review
- Sepsis in Latent Autoimmune Diabetes in Adults with Diabetic Ketoacidosis: A Case Report.Open access Macedonian journal of medical sciences · 2019Article
- Downregulation of T-Cell Transcription Factors in Adult Latent Autoimmune Diabetes with High-Titer Glutamic Acid Decaroxylase Antibody.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019Article
- Clinical features of childhood diabetes mellitus focusing on latent autoimmune diabetes.Annals of pediatric endocrinology & metabolism · 2016Article
- Altered regulatory T cell phenotype in latent autoimmune diabetes of the adults (LADA).Clinical and experimental immunology · 2016Article
- Latent Autoimmune Diabetes in Adults in the United Arab Emirates: Clinical Features and Factors Related to Insulin-Requirement.PloS one · 2015Article
- Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adult.Case reports in medicine · 2015Article
- Upregulation of proinflammatory cytokine production in response to bacterial pathogen-associated molecular patterns in dogs with diabetes mellitus undergoing insulin therapy.Journal of diabetes science and technology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Latent autoimmune diabetes in adults (LADA) accounts for 2%-12% of all cases of diabetes. Patients are typically diagnosed after 35 years of age and are often misdiagnosed as type II Diabetes Mellitus (DM). Glycemic control is initially achieved with sulfonylureas but patients eventually become insulin dependent more rapidly than with type II DM patients. Although they have a type II DM phenotype, patients have circulating beta (β) cell autoantibodies, a hallmark of type I DM. Alternative terms that have been used to describe this condition include type 1.5 diabetes, latent type I diabetes, slowly progressive Insulin Dependent Diabetes Mellitus, or youth onset diabetes of maturity. With regards to its autoimmune basis and rapid requirement for insulin, it has been suggested that LADA is a slowly progressive form of type I DM. However, recent work has revealed genetic and immunological differences between LADA and type I DM. The heterogeneity of LADA has also led to the proposal of criteria for its diagnosis by the Immunology of Diabetes Society. Although many workers have advocated a clinically oriented approach for screening of LADA, there are no universally accepted criteria for autoantibody testing in adult onset diabetes. Following recent advances in immunomodulatory therapies in type I DM, the same strategy is being explored in LADA. This review deals with the contribution of the genetic, immunological and metabolic components involved in the pathophysiology of LADA and recent approaches in screening of this distinct but heterogeneous clinical entity.
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