ArticleNutrition and metabolic insights2010
The Role of Nutrition in Sickle Cell Disease.
Article in Nutrition and metabolic insights, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04662476 (Effect of Vitamin D Supplementation on Sickle Cell Disease Hospitalisation and Related Complications Among Children in Mulago Hospital), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vitamin D Supplementation on Sickle Cell Disease Hospitalisation and Related Complications Among Children in Mulago Hospital: A Randomised Clinical Trial
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Vitamin D supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2017Pooled it
- Including malnourished siblings in treatment improves nutritional outcomes for children with sickle cell anemia in Northern Nigeria: Results from a feasibility trial.Nutrition research (New York, N.Y.) · 2025Trial
- Macronutrient and micronutrient requirements in sickle cell disease across age groups: a narrative review.Journal of community genetics · 2026Review
- Changing the Sickle Cell Nutrition Integration Narrative: Qualitative Perspectives From Sickle Cell Service Users/Carers About Nutritional Care.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Article
- "I think if we don't eat well, we will be sicker": a qualitative perspective on contributing factors to diet intake and nutrition among adults living with SCD in the United States.Journal of sickle cell disease · 2026Article
- Growth measurements in Ugandan children with sickle cell anaemia from a hydroxyurea (hydroxycarbamide) treatment trial relative to unaffected sibling controls.British journal of haematology · 2025Article
- Triaging acute chest syndrome clinical decision-making using bedside SaO2/FiO2 ratio.Blood advances · 2025Observational
- CYP2D6 Pharmacogenetics in Nigerian Sickle Cell Disease: Phase 1 of Implementing Pharmacogenomics Testing for Effective Care and Treatment in Africa (iPROTECTA) program.Gates open research · 2025Article
- Subnational mapping of anaemia and aetiologic factors in the West and Central African region.Public health nutrition · 2024Article
- Review
- Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions.Nutrients · 2024Review
- Bidirectional Relationship Between Sickle Cell Disease and Food Insecurity: Scoping Review.Health equity · 2024Article
- Risk factors in underweight older children with sickle cell anemia: a comparison of low- to high-income countries.Blood advances · 2023Article
- Intestinal barrier dysfunction in murine sickle cell disease is associated with small intestine neutrophilic inflammation, oxidative stress, and dysbiosis.FASEB bioAdvances · 2023Article
- Maternal malnutrition during pregnancy among women with sickle cell disease.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Value of DNA testing in the diagnosis of sickle-cell anemia in childhood in an environment with a high prevalence of other causes of anemia.Journal of clinical laboratory analysis · 2022Article
- Iron Deficiency Anemia: Efficacy and Limitations of Nutritional and Comprehensive Mitigation Strategies.Nutrients · 2022Review
- Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Review
- Food insecurity, housing instability, and dietary quality among children with sickle cell disease: Assessment from a single urban center.Pediatric blood & cancer · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Finding a widely available cure for sickle cell anemia (HbSS) still remains a challenge one hundred years after its discovery as a genetically inherited disease. However, growing interest in the nutritional problems of the disease has created a body of literature from researchers seeking nutritional alternatives as a means of decreasing morbidity and improving quality of life among HbSS patients. This review demonstrates that over the past 30 years the role of protein/energy deficiency in HbSS has been more clearly defined via direct measurements, leading to the concept of a relative shortage of nutrients for growth and development, despite apparently adequate dietary intakes. Although there is still a paucity of data supporting the efficacy of macronutrient supplementation, it is becoming clearer that recommended dietary allowances (RDAs) for the general population are insufficient for the sickle cell patient. A similar shortage is likely to be true for micronutrient deficiencies, including recent findings of vitamin D deficiency that may be associated with incomplete ossification and bone disease, which are well known complications of HbSS disease. We conclude that there is need for more effort and resources to be dedicated to research (including supplementation studies of larger sample size) aimed at establishing specific RDAs for HbSS patients, much like the specific RDAs developed for pregnancy and growth within the general population.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.