ReviewNature reviews. Nephrology2011
The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.
Review in Nature reviews. Nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Pharmacotherapy for hypertension in Sub-Saharan Africa: a systematic review and network meta-analysis.BMC medicine · 2020Pooled it
- Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Guideline
- New susceptibility loci associated with kidney disease in type 1 diabetes.PLoS genetics · 2012Pooled it
- Effects of Testing and Disclosing Ancestry-Specific Genetic Risk for Kidney Failure on Patients and Health Care Professionals: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Blood pressure andClinical kidney journal · 2026Article
- Trends and disparities in heart failure mortality with and without chronic kidney disease in a nationwide retrospective analysis.Scientific reports · 2025Article
- Meeting report: The Systemic Lupus International Collaborating Clinics (SLICC) World Lupus Seminar on Africa.Lupus science & medicine · 2025Article
- Multiethnic prevalence of theClinical kidney journal · 2025Article
- The changing landscape of HIV-associated kidney disease.Nature reviews. Nephrology · 2024Review
- Integration of artificial intelligence and multi-omics in kidney diseases.Fundamental research · 2023Review
- Genetic Variants ofKidney international reports · 2022Article
- Kidney disease and APOL1.Human molecular genetics · 2021Review
- Association of Serum Thyroid Hormones with the Risk and Severity of Chronic Kidney Disease Among 3563 Chinese Adults.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- VolcanoFinder: Genomic scans for adaptive introgression.PLoS genetics · 2020Article
- Association of preeclampsia with infant APOL1 genotype in African Americans.BMC medical genetics · 2020Article
- APOL1-Associated Kidney Disease in Brazil.Kidney international reports · 2019Article
- Survival of HIV infected patients on maintenance hemodialysis in Cameroon: a comparative study.BMC nephrology · 2018Article
- Blood Pressure and Arterial Stiffness in Kenyan Adolescents With the Sickle Cell Trait.American journal of epidemiology · 2018Article
- Linking Race, Cancer Outcomes, and Tissue Repair.The American journal of pathology · 2018Review
- Renal Dysfunction and Recovery following Initial Treatment of Newly Diagnosed Multiple Myeloma.International journal of nephrology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many rare kidney disorders exhibit a monogenic, Mendelian pattern of inheritance. Population-based genetic studies have identified many genetic variants associated with an increased risk of developing common kidney diseases. Strongly associated variants have potential clinical uses as predictive markers and may advance our understanding of disease pathogenesis. These principles are elegantly illustrated by a region within chromosome 22q12 that has a strong association with common forms of kidney disease. Researchers had identified DNA sequence variants in this locus that were highly associated with an increased prevalence of common chronic kidney diseases in people of African ancestry. Initial research concentrated on MYH9 as the most likely candidate gene; however, population-based whole-genome analysis enabled two independent research teams to discover more strongly associated mutations in the neighboring APOL1 gene. The powerful evolutionary selection pressure of an infectious pathogen in West Africa favored the spread of APOL1 variants that protect against a lethal form of African sleeping sickness but are highly associated with an increased risk of kidney disease. We describe the data sources, process of discovery, and reasons for initial misidentification of the candidate gene, as well as the lessons that can be learned for future population genetics research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.