ArticleThe Journal of clinical investigation2011
Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs.Frontiers in immunology · 2026Review
- Skin Aging and the Upcoming Role of Ferroptosis in Geroscience.International journal of molecular sciences · 2024Review
- Emerging Systemic Treatment Options in Atopic Dermatitis.Balkan medical journal · 2024Review
- Immune cell trafficking: a novel perspective on the gut-skin axis.Inflammation and regeneration · 2024Review
- Animal Models of IgE Anaphylaxis.Biology · 2023Review
- Intestinal inflammation alters the antigen-specific immune response to a skin commensal.Cell reports · 2022Article
- Skin immunity: dissecting the complex biology of our body's outer barrier.Mucosal immunology · 2022Review
- Intestinal helminth infection transforms the CD4Mucosal immunology · 2022Article
- Mechanisms Underlying the Skin-Gut Cross Talk in the Development of IgE-Mediated Food Allergy.Nutrients · 2020Review
- Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome.The Journal of allergy and clinical immunology · 2020Article
- Biological therapies for eosinophilic gastrointestinal diseases.The Journal of allergy and clinical immunology · 2018Review
- Maternal IgG immune complexes induce food allergen-specific tolerance in offspring.The Journal of experimental medicine · 2018Article
- Role of neural barriers in the pathogenesis and outcome ofExperimental and therapeutic medicine · 2017Article
- The Skin as a Route of Allergen Exposure: Part II. Allergens and Role of the Microbiome and Environmental Exposures.Current allergy and asthma reports · 2017Review
- RAGs and BUGS: An alliance for autoimmunity.Gut microbes · 2016Article
- Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.The Journal of allergy and clinical immunology · 2016Article
- Commensal bacteria and cutaneous immunity.Seminars in immunopathology · 2015Review
- CX₃CL1 (fractalkine) and its receptor CX₃CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin.The Journal of experimental medicine · 2014Article
- IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.Mucosal immunology · 2014Article
- Food allergy: Insights into etiology, prevention, and treatment provided by murine models.The Journal of allergy and clinical immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with atopic dermatitis (AD) often suffer from food allergy and develop flares upon skin contact with food allergens. However, it is unclear whether T cells sensitized to allergens in the gut promote this skin inflammation. To address this question, we orally immunized WT mice and mice lacking the skin-homing chemokine receptor Ccr4 (Ccr4-/- mice) with OVA and then challenged them epicutaneously with antigen. Allergic skin inflammation developed in the WT mice but not in the mutants and was characterized by epidermal thickening, dermal infiltration by eosinophils and CD4+ T cells, and upregulation of Th2 cytokines. T cells purified from mesenteric lymph nodes (MLNs) of orally immunized WT mice transferred allergic skin inflammation to naive recipients cutaneously challenged with antigen, but this effect was lost in T cells purified from Ccr4-/- mice. In addition, the ability of adoptively transferred OVA-activated T cells to home to the skin following cutaneous OVA challenge was ablated in mice that lacked lymph nodes. These results indicate that cutaneous exposure to food antigens can reprogram gut-homing effector T cells in LNs to express skin-homing receptors, eliciting skin lesions upon food allergen contact in orally sensitized AD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.