ArticleAntimicrobial agents and chemotherapy2011
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 89 citations in OpenAlex.
- One Health genomic surveillance identified high-risk carbapenem-resistant ST821 clones ofMicrobial genomics · 2026Article
- Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Whole-genome sequencing of two multidrug-resistant acinetobacter baumannii strains isolated from a neonatal intensive care unit in Egypt: a prospective cross-sectional study.BMC microbiology · 2024Article
- Exploring multidrug-resistant Klebsiella pneumoniae antimicrobial resistance mechanisms through whole genome sequencing analysis.BMC microbiology · 2023Article
- Mobile genetic elements carrying aminoglycoside resistance genes inFrontiers in microbiology · 2023Article
- Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2022Article
- WGS based analysis of acquired antimicrobial resistance in human and non-human Acinetobacter baumannii isolates from a German perspective.BMC microbiology · 2021Article
- WGS-Based Analysis of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Mobile Carbapenemase Genes inFrontiers in microbiology · 2021Review
- Mechanisms ProtectingInternational journal of molecular sciences · 2020Review
- Characterization of Extremely Drug-Resistant and HypervirulentAntibiotics (Basel, Switzerland) · 2020Article
- Article
- Genetic mechanisms of antibiotic resistance and virulence in Acinetobacter baumannii: background, challenges and future prospects.Molecular biology reports · 2020Review
- Comparative Genomics ofFrontiers in microbiology · 2020Article
- Crucial Role of the Accessory Genome in the Evolutionary Trajectory ofFrontiers in microbiology · 2020Article
- Large-Scale Identification of AbaR-Type Genomic Islands in Acinetobacter baumannii Reveals Diverse Insertion Sites and Clonal Lineage-Specific Antimicrobial Resistance Gene Profiles.Antimicrobial agents and chemotherapy · 2019Article
- Identification of Potential Virulence Factors in the Model StrainFrontiers in microbiology · 2019Article
- Fluorescence-Based Detection of Natural Transformation in Drug-Resistant Acinetobacter baumannii.Journal of bacteriology · 2018Article
- Acquisition of Tn6018-3' CS regions increases colistin MICs against Acinetobacter baumannii isolates harboring new variants of AbaRs.Folia microbiologica · 2017Article
- Occurrence of Diverse AbGRI1-Type Genomic Islands in Acinetobacter baumannii Global Clone 2 Isolates from South Korea.Antimicrobial agents and chemotherapy · 2017Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the diversity of AbaR genomic resistance islands in Acinetobacter baumannii European clone I (MLST clonal complex 1), we investigated 26 multidrug-resistant strains of this major clone isolated from hospitals in 21 cities of 10 European countries between 1984 and 2005. Each strain harbored an AbaR structure integrated at the same position in the chromosomal ATPase gene. AbaR3, including four subtypes based on variations in class 1 integron cassettes, and AbaR10 were found in 15 and 2 strains, respectively, whereas a new, unique AbaR variant was discovered in each of the other 9 strains. These new variants, designated AbaR11 to AbaR19 (19.8 kb to 57.5 kb), seem to be truncated derivatives of AbaR3, likely resulting from the deletions of its internal parts mediated by either IS26 elements (AbaR12 to AbaR19) or homologous recombination (AbaR11). AbaR3 was detected in all 10 strains isolated in 1984 to 1991, while AbaR11 to AbaR19 were carried only by strains isolated since 1997. Our results and those from previous publications suggest that AbaR3 is the original form of AbaR in European clone I, which may have provided strains of the lineage with a selective advantage facilitating their spread in European hospitals in the 1980s or before.
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