Evidence map›Paper›PMID 21536906›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2011

The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development.

Nils Elfving, Céline Davoine, Reyes Benlloch, Jeanette Blomberg, Kristoffer Brännström, Dörte Müller, Anders Nilsson, Mikael Ulfstedt, Hans Ronne, Gunnar Wingsle and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
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  6. Zinc Finger-Homeodomain Transcriptional Factors (ZHDs) in Cucumber (International journal of molecular sciences · 2024
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  18. Article
  19. Exploitation of Drought Tolerance-Related Genes for Crop Improvement.International journal of molecular sciences · 2021
    Review
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nils ElfvingDepartment of Medical Biochemistry and Biophysics, Umeå Plant Science Center, Umeå University, SE-901 87 Umeå, Sweden.
Céline Davoine
Reyes Benlloch
Jeanette Blomberg
Kristoffer Brännström
Dörte Müller
Anders Nilsson
Mikael Ulfstedt
Hans Ronne
Gunnar Wingsle
Ove Nilsson
Stefan Björklund

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development in plants is controlled by abiotic environmental cues such as day length, light quality, temperature, drought, and salinity. These signals are sensed by a variety of systems and transmitted by different signal transduction pathways. Ultimately, these pathways are integrated to control expression of specific target genes, which encode proteins that regulate development and differentiation. The molecular mechanisms for such integration have remained elusive. We here show that a linear 130-amino-acids-long sequence in the Med25 subunit of the Arabidopsis thaliana Mediator is a common target for the drought response element binding protein 2A, zinc finger homeodomain 1, and Myb-like transcription factors which are involved in different stress response pathways. In addition, our results show that Med25 together with drought response element binding protein 2A also function in repression of PhyB-mediated light signaling and thus integrate signals from different regulatory pathways.

Indexed as

EnvironmentAmino Acid SequenceArabidopsisArabidopsis ProteinsBinding SitesDNA-Binding ProteinsGene Expression Regulation, PlantMediator ComplexNuclear ProteinsProtein SubunitsSignal TransductionStress, PhysiologicalTranscription FactorsArabidopsis ProteinsDNA-Binding ProteinsMediator ComplexNuclear ProteinsPFT1 protein, ArabidopsisProtein SubunitsTranscription Factors

Identifiers

PMID21536906
PMCPMC3100966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.