ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Baroreceptor unloading in postural tachycardia syndrome augments peripheral chemoreceptor sensitivity and decreases central chemoreceptor sensitivity.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04271878 (Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Is there a relationship between hypocapnia and tachycardia in postural orthostatic tachycardia syndrome (POTS)? A systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Ventilatory response to hypercapnia is increased after 4 h of head down bed rest.Scientific reports · 2021Trial
- Determinants of Exercise Intolerance in Postural Orthostatic Tachycardia Syndrome: A Systematic Review.Exercise, sport & movement · 2025Article
- Phenylephrine alters phase synchronization between cerebral blood velocity and blood pressure in ME/CFS with orthostatic intolerance.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Anticipatory central command on standing decreases cerebral blood velocity causing hypocapnia in hyperpneic postural tachycardia syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Editorial: Hypoxia and Cardiorespiratory Control.Frontiers in physiology · 2021Article
- Postural orthostatic tachycardia syndrome: A respiratory disorder?Current research in physiology · 2021Review
- Postural orthostatic tachycardia syndrome in primary care: diagnosis, treatment and a case of African-American man presenting with POTS.BMJ case reports · 2019Article
- Assessment of Baroreflex Sensitivity Using Time-Frequency Analysis during Postural Change and Hypercapnia.Computational and mathematical methods in medicine · 2019Article
- Hemodynamic characteristics of postural hyperventilation: POTS with hyperventilation versus panic versus voluntary hyperventilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Postural Hyperventilation as a Cause of Postural Tachycardia Syndrome: Increased Systemic Vascular Resistance and Decreased Cardiac Output When Upright in All Postural Tachycardia Syndrome Variants.Journal of the American Heart Association · 2018Article
- Cardioventilatory Control in Preterm-born Children and the Risk of Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2018Article
- Chemoreflex function and brain blood flow during upright posture in men and women.Physiological reports · 2018Article
- Phenylephrine alteration of cerebral blood flow during orthostasis: effect on n-back performance in chronic fatigue syndrome.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Reduced cerebral blood flow with orthostasis precedes hypocapnic hyperpnea, sympathetic activation, and postural tachycardia syndrome.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome.Clinical science (London, England : 1979) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
While orthostatic tachycardia is the hallmark of postural tachycardia syndrome (POTS), orthostasis also initiates increased minute ventilation (Ve) and decreased end-tidal CO(2) in many patients. We hypothesized that chemoreflex sensitivity would be increased in patients with POTS. We therefore measured chemoreceptor sensitivity in 20 POTS (16 women and 4 men) and 14 healthy controls (10 women and 4 men), 16-35 yr old by exposing them to eucapneic hyperoxia (30% O(2)), eucapneic hypoxia (10% O(2)), and hypercapnic hyperoxia (30% O(2) + 5% CO(2)) while supine and during 70° head-upright tilt. Heart rate, mean arterial pressure, O(2) saturation, end-tidal CO(2), and Ve were measured. Peripheral chemoreflex sensitivity was calculated as the difference in Ve during hypoxia compared with room air divided by the change in O(2) saturation. Central chemoreflex sensitivity was determined by the difference in Ve during hypercapnia divided by the change in CO(2). POTS subjects had an increased peripheral chemoreflex sensitivity (in l·min(-1)·%oxygen(-1)) in response to hypoxia (0.42 ± 0.38 vs. 0.19 ± 0.17) but a decreased central chemoreflex sensitivity (l·min(-1)·Torr(-1)) CO(2) response (0.49 ± 0.38 vs. 1.04 ± 0.18) compared with controls. CO(2) sensitivity was also reduced in POTS subjects when supine. POTS patients are markedly sensitized to hypoxia when upright but desensitized to CO(2) while upright or supine. The interactions between orthostatic baroreflex unloading and altered chemoreflex sensitivities may explain the hyperventilation in POTS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.