ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 83 citations in OpenAlex.
- Mechanics and mechanobiology of arterial development.Biomechanics and modeling in mechanobiology · 2026Review
- Ovarian hormones moderate systolic hypertension in femaleAmerican journal of physiology. Renal physiology · 2026Article
- Ovarian Hormones Moderate Systolic Hypertension in FemalebioRxiv : the preprint server for biology · 2025Article
- Different physiologic biomechanical metrics correlate with aortic diameter increases in normal maturation compared to aneurysm progression in mice.Journal of the mechanical behavior of biomedical materials · 2025Article
- Transport across the thoracic aortic wall: implications for aneurysm pathobiology, diagnosis, and treatment.American journal of physiology. Heart and circulatory physiology · 2025Review
- Unraveling Elastic Fiber-Derived Signaling in Arterial Aging and Related Arterial Diseases.Biomolecules · 2025Review
- Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve.Scientific reports · 2024Article
- Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes.Current hypertension reports · 2024Review
- Biomechanics-mediated endocytosis in atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- Relation of Pulse Wave Velocity to Contemporaneous and Historical Blood Pressure in Female Twins.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Experimental and Mouse-Specific Computational Models of the Fbln4Cardiovascular engineering and technology · 2022Article
- Elastin, arterial mechanics, and stenosis.American journal of physiology. Cell physiology · 2022Review
- Passive biaxial mechanical behavior of newborn mouse aorta with and without elastin.Journal of the mechanical behavior of biomedical materials · 2022Article
- Elastin Insufficiency Confers Proximal and Distal Pulmonary Vasculopathy in Mice, Partially Remedied by the KFrontiers in cardiovascular medicine · 2022Article
- Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Sex modification of the association of the radial augmentation index and incident hypertension in a Chinese community-based population.Journal of geriatric cardiology : JGC · 2021Article
- Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency.Frontiers in cardiovascular medicine · 2021Article
- Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment.Communications biology · 2020Article
- Investigation of Pathophysiological Aspects of Aortic Growth, Remodeling, and Failure Using a Discrete-Fiber Microstructural Model.Journal of biomechanical engineering · 2020Article
- Extracellular matrix dynamics in vascular remodeling.American journal of physiology. Cell physiology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Increased arterial stiffness and blood pressure are characteristic of humans and adult mice with reduced elastin levels caused by aging or genetic disease. Direct associations have been shown between increased arterial stiffness and hypertension in humans, but it is not known whether changes in mechanical properties or increased blood pressure occur first. Using genetically modified mice with elastin haploinsufficiency (Eln(+/-)), we investigated the temporal relationship between arterial mechanical properties and blood pressure throughout postnatal development. Our results show that some mechanical properties are maintained constant regardless of elastin amounts. The peak diameter compliance for both genotypes occurs near the physiologic pressure at each age, which acts to provide maximum pulse dampening. The stress-strain relationships are similar between genotypes and become nonlinear near the systolic pressure for each age, which serves to limit distension under high pressure. Our results also show that some mechanical properties are affected by reduced elastin levels and that these changes occur before measurable changes in blood pressure. Eln(+/-) mice have decreased aortic diameter and compliance in ex vivo tests that are significant by postnatal day 7 and increased blood pressure that is not significant until postnatal day 14. This temporal relationship suggests that targeting large arteries to increase diameter or compliance may be an effective treatment for human hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.