ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2011
Astrocytes as regulators of synaptic function: a quest for the Ca2+ master key.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Functional Expression of Nicotinic Receptors on iPSC-Derived Astrocytes and Signalling Disturbances by a Panel of Neonicotinoid Pesticides and Their Metabolites.International journal of molecular sciences · 2026Article
- Astrocyte-Neuron Interactions in Substance Use Disorders.Advances in neurobiology · 2024Review
- Begonia-A Two-Photon Imaging Analysis Pipeline for Astrocytic CaFrontiers in cellular neuroscience · 2021Article
- Glial evolution as a determinant of human behavior and its disorders.Annals of the New York Academy of Sciences · 2020Review
- Astrocytic Calcium Dynamics Along the Pain Pathway.Frontiers in cellular neuroscience · 2020Review
- New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders.International neurourology journal · 2018Article
- Astroglial vesicular network: evolutionary trends, physiology and pathophysiology.Acta physiologica (Oxford, England) · 2018Review
- Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder.Frontiers in physiology · 2018Review
- A New Computational Model for Astrocytes and Their Role in Biologically Realistic Neural Networks.Computational intelligence and neuroscience · 2018Article
- Monitoring CaBrain research bulletin · 2018Article
- Astrocytic Atrophy FollowingFrontiers in molecular neuroscience · 2018Article
- Astroglial Vesicular Trafficking in Neurodegenerative Diseases.Neurochemical research · 2017Article
- Spatial separation of two different pathways accounting for the generation of calcium signals in astrocytes.PLoS computational biology · 2017Article
- Review
- Role of astrocytic glutamate transporter in alcohol use disorder.World journal of psychiatry · 2016Review
- Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons.Frontiers in aging neuroscience · 2016Review
- Review
- Excitable Astrocytes: Ca(2+)- and cAMP-Regulated Exocytosis.Neurochemical research · 2015Review
- Subtle modulation of ongoing calcium dynamics in astrocytic microdomains by sensory inputs.Physiological reports · 2015Article
- Astrocyte calcium signaling: from observations to functions and the challenges therein.Cold Spring Harbor perspectives in biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The emerging role of astrocytes in neural communication represents a conceptual challenge. In striking contrast to the rapid and highly space- and time-constrained machinery of neuronal spike propagation and synaptic release, astroglia appear slow and imprecise. Although a large body of independent experiments documents active signal exchange between astrocytes and neurons, some genetic models have raised doubts about the major Ca2+ -dependent molecular mechanism routinely associated with release of "gliotransmitters." A limited understanding of astrocytic Ca2+ signaling and the imperfect compatibility between physiology and experimental manipulations seem to have contributed to this conceptual bottleneck. Experimental approaches providing mechanistic insights into the diverse mechanisms of intra-astrocyte Ca2+ signaling on the nanoscale are needed to understand Ca2+ -dependent astrocytic function in vivo. This review highlights limitations and potential advantages of such approaches from the current methodological perspective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.