ArticlePsychosomatic medicine2011
Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma.
Article in Psychosomatic medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Rhesus infant nervous temperament predicts peri-adolescent central amygdala metabolism & behavioral inhibition measured by a machine-learning approach.Translational psychiatry · 2024Article
- The relationship of maternal rank, 5-HTTLPR genotype, and MAOA-LPR genotype to temperament in infant rhesus monkeys (Macaca mulatta).American journal of primatology · 2022Article
- A Novel Nonhuman Primate Model of Nonatopic Asthma.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Knowledge of Biobehavioral Organization Can Facilitate Better Science: A Review of the BioBehavioral Assessment Program at the California National Primate Research Center.Animals : an open access journal from MDPI · 2021Review
- Animal models of human mood.Neuroscience and biobehavioral reviews · 2021Review
- Ozone-Induced Oxidative Stress, Neutrophilic Airway Inflammation, and Glucocorticoid Resistance in Asthma.Frontiers in immunology · 2021Review
- Lipid metabolism is associated with temperament, corticosteroid, and hematological measures in infant rhesus monkeys (Zoological research · 2020Article
- Coppery titi monkey (Plecturocebus cupreus) pairs display coordinated behaviors in response to a simulated intruder.American journal of primatology · 2020Article
- Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatment.The Journal of allergy and clinical immunology · 2020Article
- Paternal line effects of early experiences persist across three generations in rhesus macaques.Developmental psychobiology · 2018Article
- Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future.ILAR journal · 2017Review
- Naturally Occurring Nonhuman Primate Models of Psychosocial Processes.ILAR journal · 2017Review
- Developmental consequences of behavioral inhibition: a model in rhesus monkeys (Macaca mulatta).Developmental science · 2016Article
- Asthma in an Adult Female Vervet Monkey (Chlorocebus sabaeus).Comparative medicine · 2016Article
- Paternal early experiences influence infant development through non-social mechanisms in Rhesus Macaques.Frontiers in zoology · 2015Review
- Assessing anxiety in nonhuman primates.ILAR journal · 2014Review
- Effects of acute psychosocial stress in a nonhuman primate model of allergic asthma.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
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Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether indicators of behavioral inhibition and cortisol responses to stressful situations, obtained in infancy, were associated with asthma-related measures (atopy and airway hyperresponsiveness [AHR]) approximately 2 years later.
methodsMeasures reflecting inhibited temperament and cortisol response after a 25-hour separation from mother and relocation to a novel room were obtained for 21 rhesus monkeys (mean age, 109 days; range, 91-122 days). Inhibited temperament was measured by reduced emotionality and increased vigilance. Atopy and AHR were assessed after 2 years (age range, 19-35 months) using skin tests to common aeroallergens and inhaled methacholine challenge, respectively.
resultsNo associations were found between atopy and either behavioral inhibition or cortisol levels (p > .56). Low emotionality was associated with AHR (r = 0.47, p = .03), and a trend was found for blunted cortisol responsiveness and AHR (r = 0.42, p = .06).
conclusionsInhibited temperament and blunted cortisol responsiveness may be related to the development of AHR that is common to both nonatopic and atopic asthma phenotypes and may indicate risk for nonatopic asthma specifically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.