Evidence map›Paper›PMID 21536662›Full record

ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2012

Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).

E Lucenteforte, C La Vecchia, D Silverman, G M Petersen, P M Bracci, B T Ji, C Bosetti, D Li, S Gallinger, A B Miller and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 8 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 8 syntheses or guidelines pooled it, 234 citations in OpenAlex.

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  8. Association of OGG1 Ser326Cys polymorphism and pancreatic cancer susceptibility: evidence from a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 19 institutions in 10 countries.

E LucenteforteDepartment of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri Milan, Milan, Italy.
C La Vecchia
D Silverman
G M Petersen
P M Bracci
B T Ji
C Bosetti
D Li
S Gallinger
A B Miller
H B Bueno-de-Mesquita
R Talamini
J Polesel
P Ghadirian
P A Baghurst
W Zatonski
E Fontham
W R Bamlet
E A Holly
Y T Gao
E Negri
M Hassan
M Cotterchio
J Su
P Maisonneuve
P Boffetta
E J Duell
Mario Negri Institute for Pharmacological Research · ITNational Cancer Institute · MYCentro di Riferimento Oncologico · ITThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USWinnMed · USCentre International de Recherche sur le Cancer · FREuropean Institute of Oncology · ITInstitute of Psychiatry and Neurology · PLInternational Prevention Research Institute · FRLouisiana State University · USPublic Health Ontario · CAShanghai Cancer Institute · CNToronto General Hospital · CAUniversité de Montréal · CAUniversity of Milan · ITUniversity of Toronto · CAUtrecht University · NLWomen's and Children's Hospital · AU

Funding

Cancer Risk in Human PopulationsZIACP010136 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$36.7M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI COHEN, PETER A · 2004 to 2018
$32.7M
Molecular Epidemiology of Pancreatic CancerR01CA109767 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRACCI, PAIGE M. · 2005 to 2010
$3.2M
DNA Repair Gene Polymorphysms and Pancreatic CancerR01CA098889 · NCI · DARTMOUTH COLLEGE · PI DUELL, ERIC J · 2003 to 2005
$793k
Pancreas cancer analysis-SF Bay Area case-control studyR03CA108370 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2004 to 2005
$152k
MTHFR POLYMORPHISMS IN PANCREATIC CANCER IN SF BAY AREAR03CA089726 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 2001 to 2002
$148k
PANCREATIC CANCER CASE CONTROL STUDY IN SAN FRANCISCOR01CA059706 · NCI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI HOLLY, ELIZABETH A. · 1994 to 1998
–
INVESTIGATIONS OF TUMORS THAT OCCUR MOST AMONG BLACKSN01CP051089 · CP · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · PI SCHOENGERG, JANET · 1985 to 1989
–
INVESTIGATIONS OF TUMORS THAT OCCUR MOST AMONG BLACKSN01CP051092 · CP · EMORY UNIVERSITY · PI GREENBERG, RAYMOND S · 1985 to 1988
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INVESTIGATIONS OF TUMORS THAT OCCUR MOST AMONG BLACKSN01CP051090 · CP · BARBARA ANN KARMANOS CANCER INSTITUTE · PI SWANSON, G MARIE · 1985 to 1988
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Intramural NIH HHSNCI NIH HHS CA098889NCI NIH HHS CA108370NCI NIH HHS CA109767NCI NIH HHS CA59706NCI NIH HHS CA89726NCI NIH HHS N01-CP-05225NCI NIH HHS N01-CP-05227NCI NIH HHS N01-CP-31022NCI NIH HHS N01-CP-51089NCI NIH HHS N01-CP-51090NCI NIH HHS N01-CP-51092NCI NIH HHS N01 PC035136NCI NIH HHS N01-PC-35136NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA098889NCI NIH HHS R01 CA109767NCI NIH HHS R03 CA089726NCI NIH HHS R03 CA108370
6 · The paper itself

Abstract

backgroundHeavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved.

methodsTo evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models.

resultsCompared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (≤ 4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2-2.2 for subjects drinking ≥ 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area.

conclusionThis collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.

Indexed as

AdultAgedAlcohol DrinkingCase-Control StudiesConfounding Factors, EpidemiologicFemaleHumansLogistic ModelsMaleMiddle AgedOdds RatioPancreatic NeoplasmsPancreatitisRisk FactorsSmoking

Identifiers

PMID21536662
PMCPMC3265544
OpenAlexW2138427587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.