ArticleThe Journal of allergy and clinical immunology2011
Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Beyond B cells: T and Innate Immune Mechanisms of Autoimmunity in Common Variable Immunodeficiency.Clinical reviews in allergy & immunology · 2026Review
- Evaluation of T-cell repertoire by flow cytometric analysis in primary immunodeficiencies with DNA repair defects.Scandinavian journal of immunology · 2025Article
- Altered CD73-Adenosine Signaling Linked to Infection in Patients undergoing hemodialysis.Journal of inflammation research · 2025Article
- Evaluation of Frequency of CMV Replication and Disease Complications Reveals New Cellular Defects and a Time Dependent Pattern in CVID Patients.Journal of clinical immunology · 2024Observational
- Case Report: Cytomegalovirus Disease Is an Under-Recognized Contributor to Morbidity and Mortality in Common Variable Immunodeficiency.Frontiers in immunology · 2022Article
- Downregulation of CD73 associates with T cell exhaustion in AML patients.Journal of hematology & oncology · 2019Article
- A survey of the frequency of cytomegalovirus-associated diarrhea in immunocompromised patients using a non-invasive method.Iranian journal of microbiology · 2018Article
- Clonal and constricted T cell repertoire in Common Variable Immune Deficiency.Clinical immunology (Orlando, Fla.) · 2017Article
- Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia.Scientific reports · 2017Article
- T-cell abnormalities in common variable immunodeficiency: the hidden defect.Journal of clinical pathology · 2016Review
- EBV and vitamin D status in relapsing-remitting multiple sclerosis patients with a unique cytokine signature.Medical microbiology and immunology · 2016Article
- Immune deficiency: changing spectrum of pathogens.Clinical and experimental immunology · 2015Article
- Restimulating interest in cytomegalovirus as a cofactor for HIV infection.The Journal of infectious diseases · 2015Article
- Persistent Immune Activation in CVID and the Role of IVIg in Its Suppression.Frontiers in immunology · 2014Review
- CD73 is dispensable for the regulation of inflationary CD8+ T-cells after murine cytomegalovirus infection and adenovirus immunisation.PloS one · 2014Article
- Human cytomegalovirus infection of M1 and M2 macrophages triggers inflammation and autologous T-cell proliferation.Journal of virology · 2013Article
- Article
- Chronic immune activation in common variable immunodeficiency (CVID) is associated with elevated serum levels of soluble CD14 and CD25 but not endotoxaemia.Clinical and experimental immunology · 2012Article
- Cytomegalovirus: recent progress in understanding pathogenesis and control.QJM : monthly journal of the Association of Physicians · 2012Review
- Advances in basic and clinical immunology in 2011.The Journal of allergy and clinical immunology · 2012Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCommon variable immunodeficiency is the most common primary immunodeficiency. A subset of patients has debilitating inflammatory complications.
objectivesWe investigated the role of cytomegalovirus (CMV), and the T-cell response targeted at this virus, in this inflammatory disease.
methodsPhenotypic and functional assays were used to profile CMV-specific T cells in patients with common variable immunodeficiency with and without inflammatory complications. Highly sensitive immunohistochemistry was used to detect CMV antigens at sites of inflammation.
resultsCytomegalovirus was significantly associated with inflammatory disease, which occurred in 31 of 43 (72%) virus-exposed patients and 8 of 31 (26%) naive patients (P = .0001). CMV pp65-NLVPMVATV epitope-specific CD8(+) T-cell frequencies were significantly elevated in inflammatory patients, but these cells did not show evidence of exhaustion, with low levels of programmed death-1 and high T-cell receptor avidity. Rather, they showed features consistent with high in vivo functionality and proliferative activity including reduced levels of the anti-inflammatory marker CD73 (1.67% of NLV(+) cells were CD73(+) vs 42.01% in noninflammatory patients; P = .004) and increased Ki-67 expression (37% vs 2% in noninflammatory patients; P < .0001). In vitro, the CMV-specific T cells showed high antigen-specific proliferative potential compared with cells from noninflammatory patients. By using sensitive immunohistochemistry, we detected for the first time viral antigen at the sites of inflammation, indicative of active viral replication.
conclusionOur data strongly support a direct role for CMV and a hyperreactive CMV-specific immune response in the debilitating chronic inflammatory complications of common variable immunodeficiency.
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