ReviewThe Psychiatric clinics of North America2011
Gene-environment interactions in geriatric depression.
Review in The Psychiatric clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Article
- The association between levels of brain-derived neurotrophic factor and comorbid depression in patients with cardiovascular disease: The Framingham Heart Study.Psychiatry and clinical neurosciences · 2024Article
- Genome-wide scan of depressive symptomatology in two representative cohorts in the United States and the United Kingdom.Journal of psychiatric research · 2018Article
- Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints.Neural regeneration research · 2014Article
- Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.PloS one · 2014Article
- The vascular depression hypothesis: mechanisms linking vascular disease with depression.Molecular psychiatry · 2013Review
- Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.Neuroscience · 2013Review
- Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-α treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
In older adults, several environmental challenges can potentially trigger the onset of an episode of major depression. Vulnerability to these challenges can be influenced by genetics. There is accumulating evidence for an interaction between stress and a serotonin transporter polymorphism, though there is also heterogeneity among studies. Other relevant genes include those encoding for the neuroendocrine stress axis, growth factors, and other monoaminergic systems. Each of these may interact with either predisposing traumas in early childhood or precipitating events later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.