ReviewThe Psychiatric clinics of North America2011
Late-life depression: evidence-based treatment and promising new directions for research and clinical practice.
Review in The Psychiatric clinics of North America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03128021 (Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Animal-assisted interventions for depression in older adults: an umbrella review with meta-analysis and trial sequential analysis.Aging clinical and experimental research · 2026Pooled it
- Repetitive transcranial magnetic stimulation for late-life depression: A systematic review and meta-analysis of randomized controlled trials.The Journal of international medical research · 2025Pooled it
- Trajectories in Cerebral Blood Flow Following Antidepressant Treatment in Late-Life Depression: Support for the Vascular Depression Hypothesis.The Journal of clinical psychiatry · 2018Trial
- The impact of executive function on response to cognitive behavioral therapy in late-life depression.International journal of geriatric psychiatry · 2016Trial
- Resting state functional connectivity and treatment response in late-life depression.Psychiatry research · 2013Trial
- Art therapy as an adjuvant treatment for depression in elderly women: a randomized controlled trial.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Trial
- Association between Cardiovascular-Kidney-Metabolic Syndrome and Depressive Symptoms in Middle-Aged and Older Chinese Adults: A Cross-Sectional and Longitudinal Analysis.Cardiorenal medicine · 2026Article
- Study protocol for ELders AT Ease (ELATE): a cluster randomised controlled trial of cognitive behaviour therapy to reduce depressive symptoms in aged care residents.BMC geriatrics · 2023Article
- Psychotropic medication use and future unexplained and injurious falls and fracture amongst community-dwelling older people: data from TILDA.European geriatric medicine · 2023Article
- Heterogenous Subtypes of Late-Life Depression and Their Cognitive Patterns: A Latent Class Analysis.Frontiers in psychiatry · 2022Article
- Perspectives on the Management of Vascular Depression.The American journal of psychiatry · 2018Review
- Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression.NeuroImage. Clinical · 2018Article
- Directions for Effectiveness Research to Improve Health Services for Late-Life Depression in the United States.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2016Review
- Machine learning approaches for integrating clinical and imaging features in late-life depression classification and response prediction.International journal of geriatric psychiatry · 2015Article
- The course of depression in late life as measured by the Montgomery and Asberg Depression Rating Scale in an observational study of hospitalized patients.BMC psychiatry · 2015Observational
- Applications of magnetic resonance imaging for treatment-resistant late-life depression.Dialogues in clinical neuroscience · 2015Review
- Magnetic resonance imaging predictors of treatment response in late-life depression.Journal of geriatric psychiatry and neurology · 2014Article
- The age-by-disease interaction hypothesis of late-life depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2013Review
- Transcranial magnetic stimulation for treating depression in elderly patients.Neuropsychiatric disease and treatment · 2013Article
- Treatment of depression in older adults.Current psychiatry reports · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
As the population ages, successive cohorts of older adults will experience depressive disorders. Late-life depression (LLD) carries additional risk for suicide, medical comorbidity, disability, and family caregiving burden. Although response and remission rates to pharmacotherapy and electroconvulsive therapy are comparable with those in midlife depression, relapse rates are higher, underscoring the challenge to achieve and maintain wellness. This article reviews the evidence base for LLD treatment options and provides an analysis of treatment options for difficult-to-treat LLD variants (eg, psychotic depression, vascular depression). Treatment algorithms are also reviewed based on predictors of response and promising novel treatment options.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.