ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2011
Comparative genomics and the role of lateral gene transfer in the evolution of bovine adapted Streptococcus agalactiae.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Prevalence and antimicrobial resistance ofOpen veterinary journal · 2025Pooled it
- Streptococcus agalactiae maternal colonization, antibiotic resistance and serotype profiles in Africa: a meta-analysis.Annals of clinical microbiology and antimicrobials · 2019Pooled it
- The novel prophage lysin Lys1459 exhibits broad-spectrum antibacterial activity via triple-binding domain.Applied and environmental microbiology · 2026Article
- A comparative framework of natural nisin variants: linking genetic basis to future bioengineering applications.Microbial cell factories · 2026Review
- Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch.Science advances · 2026Article
- The genetic determinants involved in metal utilization play a critical role in the growth of Streptococcus dysgalactiae subsp. dysgalactiae in milk.BMC microbiology · 2025Article
- Non-Animals : an open access journal from MDPI · 2024Article
- Genomic and functional determinants of host spectrum in Group B Streptococcus.PLoS pathogens · 2024Article
- Proteomics and metabolomics analyses of Streptococcus agalactiae isolates from human and animal sources.Scientific reports · 2023Article
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- How GBS Got Its Hump: Genomic Analysis of Group BPathogens (Basel, Switzerland) · 2022Article
- A high-quality reference genome for the fish pathogenMicrobial genomics · 2022Article
- Phylogenetic analysis and accessory genome diversity reveal insight into the evolutionary history ofFrontiers in microbiology · 2022Article
- Detection of virulence associated genes inIranian journal of veterinary research · 2022Article
- The fall and rise of group BMicrobial genomics · 2021Article
- Whole genome sequencing reveals possible host species adaptation of Streptococcus dysgalactiae.Scientific reports · 2021Article
- Genomic analysis of group B Streptococcus from milk demonstrates the need for improved biosecurity: a cross-sectional study of pastoralist camels in Kenya.BMC microbiology · 2021Article
- Antimicrobial Resistance and Virulence Factor ofInfection and drug resistance · 2021Article
- Investigation of extramammary sources of Group B Streptococcus reveals its unusual ecology and epidemiology in camels.PloS one · 2021Article
- Evidence of Common Isolates ofFrontiers in microbiology · 2021Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
In addition to causing severe invasive infections in humans, Streptococcus agalactiae, or group B Streptococcus (GBS), is also a major cause of bovine mastitis. Here we provide the first genome sequence for S. agalactiae isolated from a cow diagnosed with clinical mastitis (strain FSL S3-026). Comparison to eight S. agalactiae genomes obtained from human disease isolates revealed 183 genes specific to the bovine strain. Subsequent polymerase chain reaction (PCR) screening for the presence/absence of a subset of these loci in additional bovine and human strains revealed strong differentiation between the two groups (Fisher exact test: p<0.0001). The majority of the bovine strain-specific genes (∼ 85%) clustered tightly into eight genomic islands, suggesting these genes were acquired through lateral gene transfer (LGT). This bovine GBS also contained an unusually high proportion of insertion sequences (4.3% of the total genome), suggesting frequent genomic rearrangement. Comparison to other mastitis-causing species of bacteria provided strong evidence for two cases of interspecies LGT within the shared bovine environment: bovine S. agalactiae with Streptococcus uberis (nisin U operon) and Streptococcus dysgalactiae subsp. dysgalactiae (lactose operon). We also found evidence for LGT, involving the salivaricin operon, between the bovine S. agalactiae strain and either Streptococcus pyogenes or Streptococcus salivarius. Our findings provide insight into mechanisms facilitating environmental adaptation and acquisition of potential virulence factors, while highlighting both the key role LGT has played in the recent evolution of the bovine S. agalactiae strain, and the importance of LGT among pathogens within a shared environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.