ReviewNeurobiology of learning and memory2011
Is an epigenetic switch the key to persistent extinction?
Review in Neurobiology of learning and memory, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Optimizing exposure-based CBT for anxiety disorders via enhanced extinction: Design and methods of a multicentre randomized clinical trial.International journal of methods in psychiatric research · 2017Trial
- Epigenetics of Fear, Anxiety and Stress - Focus on Histone Modifications.Current neuropharmacology · 2024Article
- Stress, associative learning, and decision-making.Neurobiology of learning and memory · 2023Review
- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Monoamine Oxidase A Hypomethylation in Obsessive-Compulsive Disorder: Reversibility By Successful Psychotherapy?The international journal of neuropsychopharmacology · 2020Article
- The DNA methylome in panic disorder: a case-control and longitudinal psychotherapy-epigenetic study.Translational psychiatry · 2019Article
- Neuroepigenetic mechanisms underlying fear extinction: emerging concepts.Psychopharmacology · 2019Review
- Plasticity of Functional MAOA Gene Methylation in Acrophobia.The international journal of neuropsychopharmacology · 2018Article
- General Anesthesia and Young Brain: What is New?Journal of neurosurgical anesthesiology · 2018Review
- Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom.Neurobiology of learning and memory · 2017Review
- General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus.Anesthesiology · 2016Article
- MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy.Translational psychiatry · 2016Article
- Inhibition of histone deacetylase in the basolateral amygdala facilitates morphine context-associated memory formation in rats.Journal of molecular neuroscience : MN · 2015Article
- Epigenetics and memory: causes, consequences and treatments for post-traumatic stress disorder and addiction.Genes, brain, and behavior · 2015Review
- Neocortical Tet3-mediated accumulation of 5-hydroxymethylcytosine promotes rapid behavioral adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?Biochemical Society transactions · 2014Review
- Histone-mediated epigenetics in addiction.Progress in molecular biology and translational science · 2014Review
- The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference.Pharmacology, biochemistry, and behavior · 2013Article
- Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero.Nature neuroscience · 2013Article
- Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction.Biological psychiatry · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many studies of learning have demonstrated that conditioned behavior can be eliminated when previously established relations between stimuli are severed. This extinction process has been extremely important for the development of learning theories and, more recently, for delineating the neurobiological mechanisms that underlie memory. A key finding from behavioral studies of extinction is that extinction eliminates behavior without eliminating the original memory; extinguished behavior often returns with time or with a return to the context in which the original learning occurred. This persistence of the original memory after extinction creates a challenge for clinical applications that use extinction as part of a treatment intervention. Consequently, a goal of recent neurobiological research on extinction is to identify potential pharmacological targets that may result in persistent extinction. Drugs that promote epigenetic changes are particularly promising because they can result in a long-term molecular signal that, combined with the appropriate behavioral treatment, can cause persistent changes in behavior induced by extinction. We will review evidence demonstrating extinction enhancements by drugs that target epigenetic mechanisms and will describe some of the challenges that epigenetic approaches face in promoting persistent suppression of memories.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.