ReviewNeurobiology of disease2012
Ethanol modulation of gene networks: implications for alcoholism.
Review in Neurobiology of disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Non-coding RNA in alcohol use disorder by affecting synaptic plasticity.Experimental brain research · 2022Review
- Studying alcohol use disorder using Drosophila melanogaster in the era of 'Big Data'.Behavioral and brain functions : BBF · 2019Review
- Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder.Addiction biology · 2019Review
- Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster.Heredity · 2018Article
- The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption.Neuropharmacology · 2018Article
- Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.PloS one · 2018Article
- Translating Alcohol Research: Opportunities and Challenges.Alcohol research : current reviews · 2015Review
- Genetics of alcoholism.Current psychiatry reports · 2014Review
- Synaptic adaptations by alcohol and drugs of abuse: changes in microRNA expression and mRNA regulation.Frontiers in molecular neuroscience · 2014Review
- Molecular and neurologic responses to chronic alcohol use.Handbook of clinical neurology · 2014Review
- Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans.International review of neurobiology · 2014Article
- Introduction to sequencing the brain transcriptome.International review of neurobiology · 2014Review
- Genetic influences on the development of alcoholism.Current psychiatry reports · 2013Review
- Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence.BMC genomics · 2013Article
- Genes, behavior and next-generation RNA sequencing.Genes, brain, and behavior · 2013Review
- Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain.Current psychopharmacology · 2012Article
- Zebrafish: a model for the study of addiction genetics.Human genetics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Alcoholism is a complex disease caused by a confluence of environmental and genetic factors influencing multiple brain pathways to produce a variety of behavioral sequelae, including addiction. Genetic factors contribute to over 50% of the risk for alcoholism and recent evidence points to a large number of genes with small effect sizes as the likely molecular basis for this disease. Recent progress in genomics (microarrays or RNA-Seq) and genetics has led to the identification of a large number of potential candidate genes influencing ethanol behaviors or alcoholism itself. To organize this complex information, investigators have begun to focus on the contribution of gene networks, rather than individual genes, for various ethanol-induced behaviors in animal models or behavioral endophenotypes comprising alcoholism. This chapter reviews some of the methods used for constructing gene networks from genomic data and some of the recent progress made in applying such approaches to the study of the neurobiology of ethanol. We show that rapid technology development in gathering genomic data, together with sophisticated experimental design and a growing collection of analysis tools are producing novel insights for understanding the molecular basis of alcoholism and that such approaches promise new opportunities for therapeutic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.